4nkh

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{{STRUCTURE_4nkh| PDB=4nkh | SCENE= }}
 
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===Crystal structure of SspH1 LRR domain===
 
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{{ABSTRACT_PUBMED_24248594}}
 
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==Function==
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==Crystal structure of SspH1 LRR domain==
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[[http://www.uniprot.org/uniprot/SSPH1_SALT1 SSPH1_SALT1]] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host PKN1. Down-modulates production of host proinflammatory cytokines by inhibiting NF-kappa-B-dependent gene expression, probably via interaction with PKN1.<ref>PMID:10564523</ref> <ref>PMID:12819095</ref> <ref>PMID:16611232</ref> <ref>PMID:18005683</ref>
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<StructureSection load='4nkh' size='340' side='right'caption='[[4nkh]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4nkh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._14028S Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NKH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NKH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nkh OCA], [https://pdbe.org/4nkh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nkh RCSB], [https://www.ebi.ac.uk/pdbsum/4nkh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nkh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SSPH1_SALT1 SSPH1_SALT1] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host PKN1. Down-modulates production of host proinflammatory cytokines by inhibiting NF-kappa-B-dependent gene expression, probably via interaction with PKN1.<ref>PMID:10564523</ref> <ref>PMID:12819095</ref> <ref>PMID:16611232</ref> <ref>PMID:18005683</ref>
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==About this Structure==
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==See Also==
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[[4nkh]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NKH OCA].
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:024248594</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Keszei, A F.A.]]
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</StructureSection>
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[[Category: Mccormick, C.]]
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[[Category: Large Structures]]
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[[Category: Rohde, J R.]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]]
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[[Category: Sicheri, F.]]
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[[Category: Keszei AFA]]
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[[Category: Tyers, M.]]
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[[Category: Mccormick C]]
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[[Category: Xiaojing, T.]]
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[[Category: Rohde JR]]
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[[Category: Zeqiraj, E.]]
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[[Category: Sicheri F]]
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[[Category: E3 ligase substrate interaction domain]]
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[[Category: Tyers M]]
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[[Category: Leucine-rich repeat]]
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[[Category: Xiaojing T]]
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[[Category: Ligase]]
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[[Category: Zeqiraj E]]

Current revision

Crystal structure of SspH1 LRR domain

PDB ID 4nkh

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