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2rig

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[[Image:2rig.jpg|left|200px]]<br /><applet load="2rig" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2rig, resolution 2.3&Aring;" />
 
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'''CRYSTAL STRUCTURE OF RECOMBINANT RABBIT INTERFERON-GAMMA AT 2.7-ANGSTROMS RESOLUTION'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF RECOMBINANT RABBIT INTERFERON-GAMMA AT 2.7-ANGSTROMS RESOLUTION==
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The crystal structure of recombinant rabbit interferon-gamma was solved by the multiple isomorphous replacement technique at 2.7-A resolution and refined to a crystallographic R-factor of 26.2%. The interferon crystallizes with one-half of the functional dimer in the asymmetric unit, with the two polypeptide chains of the dimer related by a crystallographic 2-fold symmetry axis. The structure is predominantly alpha-helical with extensive interdigitation of the alpha-helical segments of the two polypeptide chains.
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<StructureSection load='2rig' size='340' side='right'caption='[[2rig]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2rig]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1rig 1rig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RIG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RIG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rig OCA], [https://pdbe.org/2rig PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rig RCSB], [https://www.ebi.ac.uk/pdbsum/2rig PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rig ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IFNG_RABIT IFNG_RABIT] Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ri/2rig_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rig ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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2RIG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. This structure supersedes the now removed PDB entry 1RIG. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RIG OCA].
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*[[Interferon 3D structures|Interferon 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Crystal structure of recombinant rabbit interferon-gamma at 2.7-A resolution., Samudzi CT, Burton LE, Rubin JR, J Biol Chem. 1991 Nov 15;266(32):21791-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1939201 1939201]
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[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Single protein]]
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[[Category: Burton LE]]
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[[Category: Burton, L E.]]
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[[Category: Rubin JR]]
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[[Category: Rubin, J R.]]
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[[Category: Samudzi CT]]
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[[Category: Samudzi, C T.]]
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[[Category: cytokine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:47:42 2008''
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Current revision

CRYSTAL STRUCTURE OF RECOMBINANT RABBIT INTERFERON-GAMMA AT 2.7-ANGSTROMS RESOLUTION

PDB ID 2rig

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