4hi8

{{STRUCTURE_4hi8| PDB=4hi8 | SCENE= }}

===Structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at high energy, wavelength 0.32800===

==Function==

[[http://www.uniprot.org/uniprot/ILK_HUMAN ILK_HUMAN]] Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. [[http://www.uniprot.org/uniprot/LIMS1_HUMAN LIMS1_HUMAN]] Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.

 

[[4hi8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HI8 OCA].

[[Category: Non-specific serine/threonine protein kinase]]

[[Category: Boggon, T J.]]

[[Category: Calderwood, D A.]]

[[Category: Chiswell, B P.]]

[[Category: Jakoncic, J.]]

[[Category: Stiegler, A L.]]

[[Category: Stojanoff, V.]]

[[Category: Signaling protein-signaling protein complex]]