This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2rkc
From Proteopedia
(Difference between revisions)
| (10 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:2rkc.jpg|left|200px]]<br /><applet load="2rkc" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2rkc, resolution 2.70Å" /> | ||
| - | '''Crystal structure of the measles virus hemagglutinin'''<br /> | ||
| - | == | + | ==Crystal structure of the measles virus hemagglutinin== |
| - | + | <StructureSection load='2rkc' size='340' side='right'caption='[[2rkc]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | [[ | + | <table><tr><td colspan='2'>[[2rkc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Measles_morbillivirus Measles morbillivirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RKC FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | |
| - | [[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rkc OCA], [https://pdbe.org/2rkc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rkc RCSB], [https://www.ebi.ac.uk/pdbsum/2rkc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rkc ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | [ | + | == Function == |
| - | [ | + | [https://www.uniprot.org/uniprot/HEMA_MEASE HEMA_MEASE] Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis.<ref>PMID:9811778</ref> |
| - | + | ||
| - | [ | + | |
| - | + | ||
| - | + | ||
| - | [ | + | |
| - | + | ==See Also== | |
| + | *[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Measles morbillivirus]] | ||
| + | [[Category: Colf LA]] | ||
| + | [[Category: Garcia KC]] | ||
| + | [[Category: Juo ZS]] | ||
Current revision
Crystal structure of the measles virus hemagglutinin
| |||||||||||
