4nac

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{{STRUCTURE_4nac| PDB=4nac | SCENE= }}
 
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===Crystal Structure of the N-terminal Domain of p15RS===
 
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==Function==
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==Crystal Structure of the N-terminal Domain of p15RS==
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[[http://www.uniprot.org/uniprot/RPR1A_HUMAN RPR1A_HUMAN]] Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.<ref>PMID:12470661</ref> <ref>PMID:22231121</ref>
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<StructureSection load='4nac' size='340' side='right'caption='[[4nac]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4nac]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NAC FirstGlance]. <br>
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[[4nac]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAC OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.002&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nac OCA], [https://pdbe.org/4nac PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nac RCSB], [https://www.ebi.ac.uk/pdbsum/4nac PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nac ProSAT]</span></td></tr>
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==Reference==
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</table>
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<references group="xtra"/><references/>
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== Function ==
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[[Category: Jin, Z.]]
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[https://www.uniprot.org/uniprot/RPR1A_HUMAN RPR1A_HUMAN] Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.<ref>PMID:12470661</ref> <ref>PMID:22231121</ref>
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[[Category: Mei, K.]]
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== References ==
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[[Category: Ren, F.]]
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<references/>
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[[Category: Wang, Y.]]
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__TOC__
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[[Category: Alpha helix]]
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</StructureSection>
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[[Category: Transcription]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Jin Z]]
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[[Category: Mei K]]
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[[Category: Ren F]]
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[[Category: Wang Y]]

Current revision

Crystal Structure of the N-terminal Domain of p15RS

PDB ID 4nac

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