3zjb
From Proteopedia
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| - | {{STRUCTURE_3zjb| PDB=3zjb | SCENE= }} | ||
| - | ===The structure of the TRAF domain of human TRAF4=== | ||
| - | {{ABSTRACT_PUBMED_24311986}} | ||
| - | == | + | ==The structure of the TRAF domain of human TRAF4== |
| - | [[http://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN | + | <StructureSection load='3zjb' size='340' side='right'caption='[[3zjb]], [[Resolution|resolution]] 1.84Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3zjb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZJB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZJB FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zjb OCA], [https://pdbe.org/3zjb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zjb RCSB], [https://www.ebi.ac.uk/pdbsum/3zjb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zjb ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN] Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.<ref>PMID:12023963</ref> <ref>PMID:12801526</ref> <ref>PMID:16052631</ref> <ref>PMID:16157600</ref> <ref>PMID:18953416</ref> <ref>PMID:19937093</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4) is frequently overexpressed in carcinomas, suggesting a specific role in cancer. Although TRAF4 protein is predominantly found at tight junctions (TJs) in normal mammary epithelial cells (MECs), it accumulates in the cytoplasm of malignant MECs. How TRAF4 is recruited and functions at TJs is unclear. Here we show that TRAF4 possesses a novel phosphoinositide (PIP)-binding domain crucial for its recruitment to TJs. Of interest, this property is shared by the other members of the TRAF protein family. Indeed, the TRAF domain of all TRAF proteins (TRAF1 to TRAF6) is a bona fide PIP-binding domain. Molecular and structural analyses revealed that the TRAF domain of TRAF4 exists as a trimer that binds up to three lipids using basic residues exposed at its surface. Cellular studies indicated that TRAF4 acts as a negative regulator of TJ and increases cell migration. These functions are dependent from its ability to interact with PIPs. Our results suggest that TRAF4 overexpression might contribute to breast cancer progression by destabilizing TJs and favoring cell migration. | ||
| - | + | TRAF4 Is a Novel Phosphoinositide-Binding Protein Modulating Tight Junctions and Favoring Cell Migration.,Rousseau A, McEwen AG, Poussin-Courmontagne P, Rognan D, Nomine Y, Rio MC, Tomasetto C, Alpy F PLoS Biol. 2013 Dec;11(12):e1001726. doi: 10.1371/journal.pbio.1001726. Epub 2013, Dec 3. PMID:24311986<ref>PMID:24311986</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | < | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 3zjb" style="background-color:#fffaf0;"></div> |
| - | [[Category: Alpy | + | |
| - | [[Category: McEwen | + | ==See Also== |
| - | [[Category: Nomine | + | *[[TNF receptor-associated factor 3D structures|TNF receptor-associated factor 3D structures]] |
| - | [[Category: Poussin-Courmontagne | + | == References == |
| - | [[Category: Rio | + | <references/> |
| - | [[Category: Rogna | + | __TOC__ |
| - | [[Category: Rousseau | + | </StructureSection> |
| - | [[Category: Tomasetto | + | [[Category: Homo sapiens]] |
| - | + | [[Category: Large Structures]] | |
| + | [[Category: Alpy F]] | ||
| + | [[Category: McEwen AG]] | ||
| + | [[Category: Nomine Y]] | ||
| + | [[Category: Poussin-Courmontagne P]] | ||
| + | [[Category: Rio M-C]] | ||
| + | [[Category: Rogna D]] | ||
| + | [[Category: Rousseau A]] | ||
| + | [[Category: Tomasetto C]] | ||
Current revision
The structure of the TRAF domain of human TRAF4
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