4ifh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:55, 1 March 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_4ifh| PDB=4ifh | SCENE= }}
 
-
===Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM44619===
 
-
==Function==
+
==Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM44619==
-
[[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>
+
<StructureSection load='4ifh' size='340' side='right'caption='[[4ifh]], [[Resolution|resolution]] 3.29&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4ifh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4gse 4gse]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IFH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IFH FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.286&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1EF:N-({1-[(2R)-4-(HYDROXYAMINO)-1-(NAPHTHALEN-2-YL)-4-OXOBUTAN-2-YL]-1H-1,2,3-TRIAZOL-4-YL}METHYL)-4-METHYLBENZAMIDE'>1EF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ifh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ifh OCA], [https://pdbe.org/4ifh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ifh RCSB], [https://www.ebi.ac.uk/pdbsum/4ifh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ifh ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>
-
==About this Structure==
+
==See Also==
-
[[4ifh]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4gse 4gse]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IFH OCA].
+
*[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<references group="xtra"/><references/>
+
__TOC__
-
[[Category: Insulysin]]
+
</StructureSection>
-
[[Category: Deprez, B.]]
+
[[Category: Homo sapiens]]
-
[[Category: Deprez, R.]]
+
[[Category: Large Structures]]
-
[[Category: Guo, Q.]]
+
[[Category: Deprez B]]
-
[[Category: Liang, W G.]]
+
[[Category: Deprez R]]
-
[[Category: Tang, W.]]
+
[[Category: Guo Q]]
-
[[Category: Hydrolase-hydrolase inhibitor complex]]
+
[[Category: Liang WG]]
-
[[Category: Insulin degrading enzyme]]
+
[[Category: Tang W]]

Current revision

Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM44619

PDB ID 4ifh

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4ifh"
Personal tools