4n5d

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{{STRUCTURE_4n5d| PDB=4n5d | SCENE= }}
 
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===Tailoring Small Molecules for an Allosteric Site on Procaspase-6: Cpd1===
 
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{{ABSTRACT_PUBMED_24259468}}
 
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==Function==
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==Tailoring Small Molecules for an Allosteric Site on Procaspase-6: Cpd1==
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[[http://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
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<StructureSection load='4n5d' size='340' side='right'caption='[[4n5d]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4n5d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N5D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2FQ:6-AMINO-2,8-DIMETHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE'>2FQ</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n5d OCA], [https://pdbe.org/4n5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n5d RCSB], [https://www.ebi.ac.uk/pdbsum/4n5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n5d ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
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==About this Structure==
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==See Also==
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[[4n5d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N5D OCA].
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*[[Caspase 3D structures|Caspase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:024259468</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Caspase-6]]
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[[Category: Large Structures]]
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[[Category: Murray, J M.]]
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[[Category: Murray JM]]
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[[Category: Steffek, M.]]
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[[Category: Steffek M]]
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[[Category: Allosteric]]
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[[Category: Caspase-6 zymogen]]
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[[Category: Cysteine protease]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Procaspse-6]]
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[[Category: Structure based drug design]]
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Tailoring Small Molecules for an Allosteric Site on Procaspase-6: Cpd1

PDB ID 4n5d

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