4ft8

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{{STRUCTURE_4ft8| PDB=4ft8 | SCENE= }}
 
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===E. coli Catabolite Activator Protein with Cobalt and Sulfate Ligands===
 
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==Function==
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==E. coli Catabolite Activator Protein with Cobalt and Sulfate Ligands==
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[[http://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI]] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref>
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<StructureSection load='4ft8' size='340' side='right'caption='[[4ft8]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ft8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FT8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.966&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ft8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ft8 OCA], [https://pdbe.org/4ft8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ft8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ft8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ft8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref>
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==About this Structure==
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==See Also==
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[[4ft8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FT8 OCA].
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*[[Catabolite gene activator protein 3D structures|Catabolite gene activator protein 3D structures]]
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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[[Category: Lawson, C L.]]
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</StructureSection>
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[[Category: Rao, R.]]
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[[Category: Escherichia coli K-12]]
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[[Category: Cobalt binding]]
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[[Category: Large Structures]]
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[[Category: Dna binding protein]]
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[[Category: Lawson CL]]
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[[Category: Sulfate binding]]
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[[Category: Rao R]]
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[[Category: Transcription activator]]
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[[Category: Winged helix-turn-helix]]
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Current revision

E. coli Catabolite Activator Protein with Cobalt and Sulfate Ligands

PDB ID 4ft8

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