4jep

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{{STRUCTURE_4jep| PDB=4jep | SCENE= }}
 
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===Crystal structure of Toxoplasma gondii nucleoside triphosphate diphosphohydrolase 1 (NTPDase1)===
 
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{{ABSTRACT_PUBMED_23526564}}
 
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==Function==
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==Crystal structure of Toxoplasma gondii nucleoside triphosphate diphosphohydrolase 1 (NTPDase1)==
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[[http://www.uniprot.org/uniprot/NTP2_TOXGO NTP2_TOXGO]] May perform an important processing step in the conversion of high energy nucleotides prior to uptake by the parasite. NTPAse-II has a specific activity 4.5-fold lower than NTPAse-I in hydrolysis of ATP. The primary difference between these isozymes lies in their ability to hydrolyze nucleoside triphosphate versus diphosphate substrates. While NTPAse-II hydrolyzes ATP to ADP and ADP to AMP at almost the same rate, NTPAse-I hydrolyzes ADP to AMP at a much slower rate (0.7% of the rate for ATP).
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<StructureSection load='4jep' size='340' side='right'caption='[[4jep]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4jep]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JEP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JEP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jep OCA], [https://pdbe.org/4jep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jep RCSB], [https://www.ebi.ac.uk/pdbsum/4jep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jep ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Toxoplasma gondii nucleoside triphosphate diphosphohydrolase (NTPDase) 1 was crystallized in an intermediate tetrameric conformation. The crystal structure is similar to that of T. gondii NTPDase3 and represents an inactive conformation as the activating disulfide bridge is not reduced and the active site cleft between the two domains of each monomer is open. However, the arrangement of the monomers within the tetramer differs from that of the inactive form of NTPDase3 and may represent an intermediate conformation on the path of the closure motion of the tetramer induced upon activation. (c) Proteins 2013;. (c) 2013 Wiley Periodicals, Inc.
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==About this Structure==
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The crystal structure of Toxoplasma gondii nucleoside triphosphate diphosphohydrolase 1 represents a conformational intermediate in the reductive activation mechanism of the tetrameric enzyme.,Krug U, Totzauer R, Strater N Proteins. 2013 Mar 22. doi: 10.1002/prot.24288. PMID:23526564<ref>PMID:23526564</ref>
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[[4jep]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JEP OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:023526564</ref><references group="xtra"/><references/>
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</div>
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[[Category: Nucleoside-triphosphatase]]
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<div class="pdbe-citations 4jep" style="background-color:#fffaf0;"></div>
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[[Category: Toxgo]]
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[[Category: Krug, U.]]
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==See Also==
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[[Category: Strater, N.]]
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*[[Ectonucleoside triphosphate diphosphohydrolase|Ectonucleoside triphosphate diphosphohydrolase]]
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[[Category: Totzauer, R.]]
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*[[Nucleoside triphosphatase|Nucleoside triphosphatase]]
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[[Category: Hydrolase]]
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*[[Sandbox 30008|Sandbox 30008]]
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[[Category: Ntpdase]]
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== References ==
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[[Category: Phosphatase]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Toxoplasma gondii]]
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[[Category: Krug U]]
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[[Category: Strater N]]
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[[Category: Totzauer R]]

Current revision

Crystal structure of Toxoplasma gondii nucleoside triphosphate diphosphohydrolase 1 (NTPDase1)

PDB ID 4jep

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