2mfp
From Proteopedia
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| - | {{STRUCTURE_2mfp| PDB=2mfp | SCENE= }} | ||
| - | ===Solution structure of the circular g-domain analog from the wheat metallothionein Ec-1=== | ||
| - | {{ABSTRACT_PUBMED_24284492}} | ||
| - | == | + | ==Solution structure of the circular g-domain analog from the wheat metallothionein Ec-1== |
| - | [[http://www.uniprot.org/uniprot/EC1_WHEAT EC1_WHEAT | + | <StructureSection load='2mfp' size='340' side='right'caption='[[2mfp]]' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2mfp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Triticum_aestivum Triticum aestivum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MFP FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mfp OCA], [https://pdbe.org/2mfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mfp RCSB], [https://www.ebi.ac.uk/pdbsum/2mfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mfp ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/EC1_WHEAT EC1_WHEAT] Binds 5 molecules of zinc. May have a role in Zn(2+) homeostasis during embryogenesis. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The first cyclic analog of a metallothionein (MT) was prepared and analyzed by UV and (magnetic) circular dichroism spectroscopy, ESI-MS as well as NMR spectroscopy. Results reveal that the evaluated cyclic g-Ec-1 domain of the wheat MT Ec-1 retains its ability to coordinate two Zn(II) or Cd(II) ions and adopts a three-dimensional structure that is highly similar to the one of the linear wild-type form. However, the reduced flexibility of the protein backbone facilitates structure solution significantly and results in a certain stabilization of metal binding to the protein. | ||
| - | + | Solution Structure of the Circular gamma-Domain Analog from the Wheat Metallothionein Ec-1.,Tarasava K, Johannsen S, Freisinger E Molecules. 2013 Nov 21;18(11):14414-29. doi: 10.3390/molecules181114414. PMID:24284492<ref>PMID:24284492</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | < | + | </div> |
| - | + | <div class="pdbe-citations 2mfp" style="background-color:#fffaf0;"></div> | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Triticum aestivum]] |
| - | + | [[Category: Freisinger E]] | |
| + | [[Category: Johannsen S]] | ||
| + | [[Category: Tarasava K]] | ||
Current revision
Solution structure of the circular g-domain analog from the wheat metallothionein Ec-1
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