3rnk

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{{STRUCTURE_3rnk| PDB=3rnk | SCENE= }}
 
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===Crystal structure of the complex between mouse PD-1 mutant and PD-L2 IgV domain===
 
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==Function==
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==Crystal structure of the complex between mouse PD-1 mutant and PD-L2 IgV domain==
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[[http://www.uniprot.org/uniprot/PDCD1_MOUSE PDCD1_MOUSE]] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors (By similarity). [[http://www.uniprot.org/uniprot/PD1L2_MOUSE PD1L2_MOUSE]] Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.<ref>PMID:11283156</ref> <ref>PMID:11224527</ref> <ref>PMID:12719480</ref>
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<StructureSection load='3rnk' size='340' side='right'caption='[[3rnk]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3rnk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RNK FirstGlance]. <br>
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[[3rnk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNK OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rnk OCA], [https://pdbe.org/3rnk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rnk RCSB], [https://www.ebi.ac.uk/pdbsum/3rnk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rnk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDCD1_MOUSE PDCD1_MOUSE] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors (By similarity).
==See Also==
==See Also==
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*[[Cell death protein|Cell death protein]]
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*[[Cell death protein 3D structures|Cell death protein 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<references group="xtra"/><references/>
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[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Almo, S C.]]
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[[Category: Almo SC]]
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[[Category: Cao, E]]
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[[Category: Cao E]]
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[[Category: Lazar-Molnar, E.]]
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[[Category: Lazar-Molnar E]]
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[[Category: Nathenson, S G.]]
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[[Category: Nathenson SG]]
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[[Category: Ramagopal, U A.]]
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[[Category: Ramagopal UA]]
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[[Category: B7-dc]]
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[[Category: Complex]]
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[[Category: Costimulatory]]
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[[Category: Igv]]
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[[Category: Immune system]]
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[[Category: Pd-1]]
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[[Category: Pd-l2]]
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[[Category: Programmed death-1 ligand 2]]
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Current revision

Crystal structure of the complex between mouse PD-1 mutant and PD-L2 IgV domain

PDB ID 3rnk

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