4m4x

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{{STRUCTURE_4m4x| PDB=4m4x | SCENE= }}
 
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===Structure and Dimerization Properties of the Aryl Hydrocarbon Receptor (AHR) PAS-A Domain===
 
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{{ABSTRACT_PUBMED_24001774}}
 
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==Function==
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==Structure and Dimerization Properties of the Aryl Hydrocarbon Receptor (AHR) PAS-A Domain==
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[[http://www.uniprot.org/uniprot/AHR_MOUSE AHR_MOUSE]] Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues.<ref>PMID:1314586</ref> <ref>PMID:7961644</ref> <ref>PMID:7969080</ref> <ref>PMID:8806883</ref> <ref>PMID:9427285</ref> <ref>PMID:10973493</ref> <ref>PMID:10639156</ref>
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<StructureSection load='4m4x' size='340' side='right'caption='[[4m4x]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4m4x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M4X FirstGlance]. <br>
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[[4m4x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4X OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.551&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m4x OCA], [https://pdbe.org/4m4x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m4x RCSB], [https://www.ebi.ac.uk/pdbsum/4m4x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m4x ProSAT]</span></td></tr>
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==Reference==
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</table>
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<ref group="xtra">PMID:024001774</ref><references group="xtra"/><references/>
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== Function ==
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[[Category: Lk3 transgenic mice]]
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[https://www.uniprot.org/uniprot/AHR_MOUSE AHR_MOUSE] Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues.<ref>PMID:1314586</ref> <ref>PMID:7961644</ref> <ref>PMID:7969080</ref> <ref>PMID:8806883</ref> <ref>PMID:9427285</ref> <ref>PMID:10973493</ref> <ref>PMID:10639156</ref>
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[[Category: Kim, Y.]]
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== References ==
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[[Category: Potluri, N.]]
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<references/>
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[[Category: Rastinejad, F.]]
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__TOC__
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[[Category: Wu, D.]]
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</StructureSection>
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[[Category: Ahr]]
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[[Category: Large Structures]]
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[[Category: Arnt]]
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[[Category: Mus musculus]]
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[[Category: Dimer]]
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[[Category: Kim Y]]
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[[Category: Interface]]
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[[Category: Potluri N]]
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[[Category: Pas-a]]
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[[Category: Rastinejad F]]
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[[Category: Transcription]]
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[[Category: Wu D]]
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[[Category: Transcription factor]]
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Structure and Dimerization Properties of the Aryl Hydrocarbon Receptor (AHR) PAS-A Domain

PDB ID 4m4x

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