2mio
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2mio is ON HOLD Authors: Xu, X., Eletsky, A., Pulavarti, S.V.S.R.K., Wang, H., Janjua, H., Xiao, R., Everett, J.K., Sukumaran, D.T., Montelione, G.T...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution NMR Structure of SH3 Domain 1 of Rho GTPase-activating Protein 10 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR9129A== | |
| + | <StructureSection load='2mio' size='340' side='right'caption='[[2mio]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2mio]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MIO FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mio OCA], [https://pdbe.org/2mio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mio RCSB], [https://www.ebi.ac.uk/pdbsum/2mio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mio ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RHG10_HUMAN RHG10_HUMAN] GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Rho GTPase activating protein 3D structures|Rho GTPase activating protein 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Eletsky A]] | ||
| + | [[Category: Everett JK]] | ||
| + | [[Category: Janjua H]] | ||
| + | [[Category: Montelione GT]] | ||
| + | [[Category: Pulavarti SVSRK]] | ||
| + | [[Category: Sukumaran DK]] | ||
| + | [[Category: Szyperski T]] | ||
| + | [[Category: Wang H]] | ||
| + | [[Category: Xiao R]] | ||
| + | [[Category: Xu X]] | ||
Current revision
Solution NMR Structure of SH3 Domain 1 of Rho GTPase-activating Protein 10 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR9129A
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Categories: Homo sapiens | Large Structures | Eletsky A | Everett JK | Janjua H | Montelione GT | Pulavarti SVSRK | Sukumaran DK | Szyperski T | Wang H | Xiao R | Xu X
