2miq
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution NMR Structure of PHD Type 1 Zinc Finger Domain 1 of Lysine-specific Demethylase Lid from Drosophila melanogaster, Northeast Structural Genomics Consortium (NESG) Target FR824J== | |
| - | + | <StructureSection load='2miq' size='340' side='right'caption='[[2miq]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2miq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MIQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2miq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2miq OCA], [https://pdbe.org/2miq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2miq RCSB], [https://www.ebi.ac.uk/pdbsum/2miq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2miq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KDM5_DROME KDM5_DROME] Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Specifically demethylates trimethylated H3 'Lys-4'. Required for the correct regulation of homeotic genes during development.<ref>PMID:11014813</ref> <ref>PMID:17311883</ref> <ref>PMID:17351631</ref> <ref>PMID:17351630</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Drosophila melanogaster]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Eletsky A]] | ||
| + | [[Category: Everett JK]] | ||
| + | [[Category: Janjua H]] | ||
| + | [[Category: Maglaqui M]] | ||
| + | [[Category: Montelione GT]] | ||
| + | [[Category: Shastry R]] | ||
| + | [[Category: Sukumaran DK]] | ||
| + | [[Category: Szyperski T]] | ||
| + | [[Category: Xiao R]] | ||
| + | [[Category: Xu X]] | ||
Current revision
Solution NMR Structure of PHD Type 1 Zinc Finger Domain 1 of Lysine-specific Demethylase Lid from Drosophila melanogaster, Northeast Structural Genomics Consortium (NESG) Target FR824J
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