4jp4

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'''Unreleased structure'''
 
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The entry 4jp4 is ON HOLD
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==Mmp13 in complex with a reverse hydroxamate Zn-binder==
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<StructureSection load='4jp4' size='340' side='right'caption='[[4jp4]], [[Resolution|resolution]] 1.43&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4jp4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JP4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JP4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.43&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZ4:N-[(2S)-4-(5-FLUOROPYRIMIDIN-2-YL)-1-({4-[5-(2,2,2-TRIFLUOROETHOXY)PYRIMIDIN-2-YL]PIPERAZIN-1-YL}SULFONYL)BUTAN-2-YL]-N-HYDROXYFORMAMIDE'>AZ4</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jp4 OCA], [https://pdbe.org/4jp4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jp4 RCSB], [https://www.ebi.ac.uk/pdbsum/4jp4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jp4 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MMP13_HUMAN MMP13_HUMAN] Defects in MMP13 are the cause of spondyloepimetaphyseal dysplasia Missouri type (SEMD-MO) [MIM:[https://omim.org/entry/602111 602111]. A bone disease characterized by moderate to severe metaphyseal changes, mild epiphyseal involvement, rhizomelic shortening of the lower limbs with bowing of the femora and/or tibiae, coxa vara, genu varum and pear-shaped vertebrae in childhood. Epimetaphyseal changes improve with age.<ref>PMID:16167086</ref> Defects in MMP13 are the cause of metaphyseal anadysplasia type 1 (MANDP1) [MIM:[https://omim.org/entry/602111 602111]. Metaphyseal anadysplasia consists of an abnormal bone development characterized by severe skeletal changes that, in contrast with the progressive course of most other skeletal dysplasias, resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia.<ref>PMID:19615667</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/MMP13_HUMAN MMP13_HUMAN] Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process.
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Authors: Gerhardt, S., Hargreaves, D.
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==See Also==
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*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
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Description: Mmp13 in complex with AZD6605
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Gerhardt S]]
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[[Category: Hargreaves D]]

Current revision

Mmp13 in complex with a reverse hydroxamate Zn-binder

PDB ID 4jp4

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