4o45

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(New page: '''Unreleased structure''' The entry 4o45 is ON HOLD Authors: Qin, S., Xu, C., Tempel, W., Arrowsmith,C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium, Structur...)
Current revision (12:37, 1 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4o45 is ON HOLD
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==WDR5 in complex with influenza NS1 C-terminal tail==
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<StructureSection load='4o45' size='340' side='right'caption='[[4o45]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4o45]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus_H3N2 Influenza A virus H3N2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O45 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O45 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o45 OCA], [https://pdbe.org/4o45 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o45 RCSB], [https://www.ebi.ac.uk/pdbsum/4o45 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o45 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
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Authors: Qin, S., Xu, C., Tempel, W., Arrowsmith,C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
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==See Also==
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*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
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Description: WDR5 in complex with influenza NS1 C-terminal tail
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Influenza A virus H3N2]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra C]]
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[[Category: Edwards AM]]
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[[Category: Min J]]
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[[Category: Qin S]]
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[[Category: Tempel W]]
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[[Category: Xu C]]

Current revision

WDR5 in complex with influenza NS1 C-terminal tail

PDB ID 4o45

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