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2v0e

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[[Image:2v0e.gif|left|200px]]<br /><applet load="2v0e" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2v0e" />
 
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'''BRK DOMAIN FROM HUMAN CHD7'''<br />
 
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==Overview==
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==BRK domain from human CHD7==
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<StructureSection load='2v0e' size='340' side='right'caption='[[2v0e]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2v0e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V0E FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ckc|2ckc]], [[2v0f|2v0f]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0e OCA], [https://pdbe.org/2v0e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v0e RCSB], [https://www.ebi.ac.uk/pdbsum/2v0e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v0e ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/2v0e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v0e ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
CHD7 is a member of the chromodomain helicase DNA binding domain (CHD) family of ATP-dependent chromatin remodelling enzymes. It is mutated in CHARGE syndrome, a multiple congenital anomaly condition. CHD7 is one of a subset of CHD proteins, unique to metazoans that contain the BRK domain, a protein module also found in the Brahma/BRG1 family of helicases. We describe here the NMR solution structure of the two BRK domains of CHD7. Each domain has a compact betabetaalphabeta fold. The second domain has a C-terminal extension consisting of two additional helices. The structure differs from those of other domains present in chromatin-associated proteins.
CHD7 is a member of the chromodomain helicase DNA binding domain (CHD) family of ATP-dependent chromatin remodelling enzymes. It is mutated in CHARGE syndrome, a multiple congenital anomaly condition. CHD7 is one of a subset of CHD proteins, unique to metazoans that contain the BRK domain, a protein module also found in the Brahma/BRG1 family of helicases. We describe here the NMR solution structure of the two BRK domains of CHD7. Each domain has a compact betabetaalphabeta fold. The second domain has a C-terminal extension consisting of two additional helices. The structure differs from those of other domains present in chromatin-associated proteins.
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==Disease==
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Solution structure of the BRK domains from CHD7.,Allen MD, Religa TL, Freund SM, Bycroft M J Mol Biol. 2007 Aug 31;371(5):1135-40. Epub 2007 Jun 9. PMID:17603073<ref>PMID:17603073</ref>
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Known diseases associated with this structure: CHARGE syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=608892 608892]], Scoliosis, idiopathic 3 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=608892 608892]]
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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2V0E is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0E OCA].
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</div>
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<div class="pdbe-citations 2v0e" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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Solution structure of the BRK domains from CHD7., Allen MD, Religa TL, Freund SM, Bycroft M, J Mol Biol. 2007 Aug 31;371(5):1135-40. Epub 2007 Jun 9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17603073 17603073]
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*[[Chromodomain-helicase-DNA-binding protein 3D structures|Chromodomain-helicase-DNA-binding protein 3D structures]]
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[[Category: Homo sapiens]]
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*[[Helicase 3D structures|Helicase 3D structures]]
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[[Category: Single protein]]
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== References ==
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[[Category: Allen, M D.]]
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<references/>
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[[Category: Bycroft, M.]]
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__TOC__
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[[Category: Freund, S M.V.]]
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</StructureSection>
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[[Category: Religa, T L.]]
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[[Category: Human]]
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[[Category: atp-binding]]
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[[Category: Large Structures]]
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[[Category: brk domain]]
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[[Category: Allen, M D]]
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[[Category: charge syndrome]]
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[[Category: Bycroft, M]]
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[[Category: chd7]]
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[[Category: Freund, S M.V]]
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[[Category: chromatin regulator]]
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[[Category: Religa, T L]]
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[[Category: disease mutation]]
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[[Category: Atp-binding]]
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[[Category: dna-binding]]
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[[Category: Brk domain]]
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[[Category: helicase]]
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[[Category: Charge syndrome]]
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[[Category: hydrolase]]
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[[Category: Chd7]]
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[[Category: nuclear protein]]
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[[Category: Chromatin regulator]]
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[[Category: nucleotide-binding]]
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[[Category: Disease mutation]]
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[[Category: phosphorylation]]
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[[Category: Dna-binding]]
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[[Category: transcription]]
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[[Category: Helicase]]
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[[Category: transcription regulation]]
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[[Category: Hydrolase]]
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[[Category: Nuclear protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:52:06 2008''
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[[Category: Nucleotide-binding]]
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[[Category: Phosphorylation]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]

Current revision

BRK domain from human CHD7

PDB ID 2v0e

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