4j2c

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{{STRUCTURE_4j2c| PDB=4j2c | SCENE= }}
 
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===GARP-SNARE Interaction===
 
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{{ABSTRACT_PUBMED_23932592}}
 
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==Function==
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==GARP-SNARE Interaction==
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[[http://www.uniprot.org/uniprot/STX6_HUMAN STX6_HUMAN]] Involved in intracellular vesicle trafficking. [[http://www.uniprot.org/uniprot/VPS51_HUMAN VPS51_HUMAN]] Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi networkl (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN.<ref>PMID:20685960</ref>
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<StructureSection load='4j2c' size='340' side='right'caption='[[4j2c]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4j2c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J2C FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.801&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j2c OCA], [https://pdbe.org/4j2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j2c RCSB], [https://www.ebi.ac.uk/pdbsum/4j2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j2c ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/STX6_HUMAN STX6_HUMAN] Involved in intracellular vesicle trafficking.
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==About this Structure==
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==See Also==
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[[4j2c]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J2C OCA].
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*[[Syntaxin 3D structures|Syntaxin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:023932592</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Abascal-Palacios, G.]]
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[[Category: Large Structures]]
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[[Category: Bonifacino, J S.]]
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[[Category: Abascal-Palacios G]]
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[[Category: Hierro, A.]]
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[[Category: Bonifacino JS]]
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[[Category: Rojas, A L.]]
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[[Category: Hierro A]]
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[[Category: Schindler, C.]]
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[[Category: Rojas AL]]
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[[Category: Protein transport]]
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[[Category: Schindler C]]
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[[Category: Tethering complex]]
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Current revision

GARP-SNARE Interaction

PDB ID 4j2c

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