4km2

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{{STRUCTURE_4km2| PDB=4km2 | SCENE= }}
 
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===Crystal structure of Dihydrofolate reductase from Mycobacterium tuberculosis in an open conformation in complex with trimethoprim===
 
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{{ABSTRACT_PUBMED_24210757}}
 
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==Function==
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==Crystal structure of Dihydrofolate reductase from Mycobacterium tuberculosis in an open conformation in complex with trimethoprim==
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[[http://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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<StructureSection load='4km2' size='340' side='right'caption='[[4km2]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4km2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KM2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KM2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATR:2-MONOPHOSPHOADENOSINE-5-DIPHOSPHATE'>ATR</scene>, <scene name='pdbligand=TOP:TRIMETHOPRIM'>TOP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4km2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4km2 OCA], [https://pdbe.org/4km2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4km2 RCSB], [https://www.ebi.ac.uk/pdbsum/4km2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4km2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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==About this Structure==
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==See Also==
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[[4km2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KM2 OCA].
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:024210757</ref><references group="xtra"/><references/>
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[[Category: Large Structures]]
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[[Category: Dihydrofolate reductase]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Blundell, T L.]]
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[[Category: Blundell TL]]
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[[Category: Dias, M V.B]]
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[[Category: Dias MVB]]
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[[Category: Tyrakis, P.]]
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[[Category: Tyrakis P]]
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[[Category: Oxidoreductase]]
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[[Category: Reductase]]
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Current revision

Crystal structure of Dihydrofolate reductase from Mycobacterium tuberculosis in an open conformation in complex with trimethoprim

PDB ID 4km2

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