4lh6
From Proteopedia
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| - | {{STRUCTURE_4lh6| PDB=4lh6 | SCENE= }} | ||
| - | ===Crystal structure of a LigA inhibitor=== | ||
| - | {{ABSTRACT_PUBMED_24287382}} | ||
| - | == | + | ==Crystal structure of a LigA inhibitor== |
| - | [[http://www.uniprot.org/uniprot/DNLJ_ENTFA DNLJ_ENTFA | + | <StructureSection load='4lh6' size='340' side='right'caption='[[4lh6]], [[Resolution|resolution]] 1.65Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4lh6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LH6 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1X7:4-AMINO-2-BROMOTHIENO[3,2-C]PYRIDINE-7-CARBOXAMIDE'>1X7</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lh6 OCA], [https://pdbe.org/4lh6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lh6 RCSB], [https://www.ebi.ac.uk/pdbsum/4lh6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lh6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DNLJ_ENTFA DNLJ_ENTFA] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity). | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[DNA ligase 3D structures|DNA ligase 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Enterococcus faecalis V583]] | |
| - | [[Category: Benenato | + | [[Category: Large Structures]] |
| - | [[Category: Boriack-Sjodin | + | [[Category: Benenato K]] |
| - | [[Category: Davis | + | [[Category: Boriack-Sjodin PA]] |
| - | [[Category: Gao | + | [[Category: Davis H]] |
| - | [[Category: Jahic | + | [[Category: Gao N]] |
| - | [[Category: Mcguire | + | [[Category: Jahic H]] |
| - | [[Category: Prince | + | [[Category: Mcguire HM]] |
| - | [[Category: Stokes | + | [[Category: Prince DB]] |
| - | [[Category: Wang | + | [[Category: Stokes SS]] |
| - | + | [[Category: Wang H]] | |
| - | + | ||
Current revision
Crystal structure of a LigA inhibitor
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