4iio

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:49, 25 December 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_4iio| PDB=4iio | SCENE= }}
 
-
===Crystal Structure of the Second SH3 Domain of ITSN2 Bound with a Synthetic Peptide===
 
-
==Function==
+
==Crystal Structure of the Second SH3 Domain of ITSN2 Bound with a Synthetic Peptide==
-
[[http://www.uniprot.org/uniprot/ITSN2_HUMAN ITSN2_HUMAN]] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR).<ref>PMID:19458185</ref> <ref>PMID:22648170</ref>
+
<StructureSection load='4iio' size='340' side='right'caption='[[4iio]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4iio]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IIO FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iio OCA], [https://pdbe.org/4iio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iio RCSB], [https://www.ebi.ac.uk/pdbsum/4iio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iio ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ITSN2_HUMAN ITSN2_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR).<ref>PMID:19458185</ref> <ref>PMID:22648170</ref>
-
==About this Structure==
+
==See Also==
-
[[4iio]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIO OCA].
+
*[[Intersectin|Intersectin]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<references group="xtra"/><references/>
+
__TOC__
-
[[Category: Arrowsmith, C H.]]
+
</StructureSection>
-
[[Category: Bountra, C.]]
+
[[Category: Homo sapiens]]
-
[[Category: Dong, A.]]
+
[[Category: Large Structures]]
-
[[Category: Edwards, A M.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Gu, J.]]
+
[[Category: Bountra C]]
-
[[Category: Guan, X.]]
+
[[Category: Dong A]]
-
[[Category: Huang, H.]]
+
[[Category: Edwards AM]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Gu J]]
-
[[Category: Sidhu, S.]]
+
[[Category: Guan X]]
-
[[Category: Tempel, W.]]
+
[[Category: Huang H]]
-
[[Category: Tong, Y.]]
+
[[Category: Sidhu S]]
-
[[Category: Endocytosis]]
+
[[Category: Tempel W]]
-
[[Category: Itsn2]]
+
[[Category: Tong Y]]
-
[[Category: Protein-peptide complex]]
+
-
[[Category: Sgc]]
+
-
[[Category: Sh3 domain]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Structural genomics consortium]]
+
-
[[Category: Synthetic peptide]]
+

Current revision

Crystal Structure of the Second SH3 Domain of ITSN2 Bound with a Synthetic Peptide

PDB ID 4iio

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4iio"
Personal tools