This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Adenosine kinase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: <StructureSection load='1bx4' size='350' side='right' caption='Structure of human adenosine kinase complex with adenosine (PDB entry 1bx4)' scene=''> '''Adenosine kinase''' (AdK) c...)
Current revision (11:07, 28 February 2019) (edit) (undo)
 
(21 intermediate revisions not shown.)
Line 1: Line 1:
 +
<StructureSection load='1bx4' size='350' side='right' caption='Structure of human adenosine kinase complex with adenosine, Mg+2 (small light green) and Cl- (large, deep green) ions (PDB entry [[1bx4]])' scene='57/573962/Cv/1'>
-
<StructureSection load='1bx4' size='350' side='right' caption='Structure of human adenosine kinase complex with adenosine (PDB entry [[1bx4]])' scene=''>
+
== Function ==
-
'''Adenosine kinase''' (AdK) catalyzes the transfer of phosphate from ATP to adenosine to produce AMP. AdK deficiency causes hypermethioninemia.
+
'''Adenosine kinase''' (AdK) catalyzes the transfer of phosphate from ATP to adenosine to produce AMP. AMP-PCP is a non-hydrolyzable ATP analog.<ref>PMID:18560757</ref>
-
==3D structures of adenosine kinase==
+
== Disease ==
-
[[1lio]] – TgAdK – ''Toxoplasma gondii''<br />
+
AdK deficiency causes hypermethioninemia. Overexpression of AdK in the brain leads to decrease of adenosine and is believed as the main cause of epilepsy.
-
===Adenosine kinase binary complex===
+
== Structural highlights ==
-
[[1bx4]] – hAdK + adenosine - human<br />
+
AdK consists of a <scene name='57/573962/Cv/4'>large α/β domain with 9 β strands and 8 α helices and a small capping α/β domain with 5 β strands and 2 α helices</scene> (PDB entry [[1bx4]]).<ref>PMID:9843365</ref>
-
[[2i6a]], [[2i6b]] – hAdK + prodrug <br />
+
*<scene name='57/573962/Cv/6'>1st adenosine binding site</scene>. Water molecules are shown as red spheres.
-
[[1dgm]], [[1lik]] – TgAdK + adenosine <br />
+
*<scene name='57/573962/Cv/7'>Cl coordination site</scene>.
-
[[2a9y]] – TgAdK (mutant) + dimethyladenosine <br />
+
*<scene name='57/573962/Cv/8'>Cl/Mg cluster coordination site</scene>.
-
[[2abs]] – TgAdK (mutant) + AMP-PCP<br />
+
*<scene name='57/573962/Cv/11'>2nd adenosine binding site</scene>.
-
[[2aa0]] – TgAdK (mutant) + methylthiopurine <br />
+
 
-
[[2pkk]] – MtAdK + fluoroadenosine – ''Mycobacterium tuberculosis''<br />
+
==3D structures of adenosine kinase==
-
[[2pkn]] – MtAdK + AMP-PCP<br />
+
[[Adenosine kinase 3D structures]]
-
[[2pkm]] – MtAdK + adenosine <br />
+
-
===Adenosine kinase ternary complex===
+
</StructureSection>
-
[[2a9z]] – TgAdK (mutant) + adenosine + AMP-PCP<br />
+
== References ==
-
[[2a9z]] – TgAdK (mutant) + dimethyladenosine + AMP-PCP<br />
+
<references/>
-
[[1lij]] – TgAdK + prodrug + AMP-PCP<br />
+
[[Category:Topic Page]]
-
[[2ab8]] – TgAdK (mutant) + methylthiopurine + AMP-PCP<br />
+

Current revision

Structure of human adenosine kinase complex with adenosine, Mg+2 (small light green) and Cl- (large, deep green) ions (PDB entry 1bx4)

Drag the structure with the mouse to rotate

References

  1. ↑ Park J, Gupta RS. Adenosine kinase and ribokinase--the RK family of proteins. Cell Mol Life Sci. 2008 Sep;65(18):2875-96. doi: 10.1007/s00018-008-8123-1. PMID:18560757 doi:http://dx.doi.org/10.1007/s00018-008-8123-1
  2. ↑ Mathews II, Erion MD, Ealick SE. Structure of human adenosine kinase at 1.5 A resolution. Biochemistry. 1998 Nov 10;37(45):15607-20. PMID:9843365 doi:10.1021/bi9815445

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Adenosine_kinase"
Personal tools