Protein disulfide oxidoreductase

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{{STRUCTURE_2hi7| PDB=2hi7 | SIZE=400| SCENE= |right|CAPTION=E. coli DsbA (grey) and DsbB (green) complex with ubiquinone and Zn+2 ion (grey), [[2hi7]] }}
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<StructureSection load='' size='350' side='right' caption='DsbA (PDB entry [[3bci]])' scene='49/490083/Cv/1'>
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__TOC__
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== Function ==
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'''Protein disulfide oxidoreductase''' (PDOR) catalyzes disulfide bond formation in proteins and is critically important in protein folding. In bacteria PDOR are known as DsbA and DsbB. PDOR catalyze dithiol-disulfide exchange reactions, i.e., conversion of RSSR and R’SH to R’SSR’ and RSH<ref>PMID:15291821</ref>.
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== Structural highlights ==
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'''Protein disulfide oxidoreductase''' (PDOR) catalyzes disulfide bond formation in proteins and is critically important in protein folding. In bacteria PDOR are known as DsbA and DsbB. PDOR catalyze dithiol-disulfide exchange reactions, i.e., conversion of RSSR and R’SH to R’SSR’ and RSH. PDOR contains the sequence CXXC in the active site. The 2 cysteines can undergo reversible oxidation-reduction in the catalytic process.
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PDOR DsnA contains the <scene name='49/490083/Cv/3'>sequence CXXC</scene> in the active site. The 2 cysteines can undergo reversible oxidation-reduction in the catalytic process<ref>PMID:18007049</ref>.
==3D structures of protein disulfide oxidoreductase==
==3D structures of protein disulfide oxidoreductase==
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[[1a8l]] – PDOR – ''Pyrococcus furiosus''<br />
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[[Protein disulfide oxidoreductase 3D structures]]
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[[1bq7]] – EcDsbA (mutant) – ''Escherichia coli''<br />
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[[2hi7]], [[3e9j]], [[2zup]] - EcDsbA (mutant) + EcDsbB (mutant)<br />
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[[2leg]] - EcDsbA (mutant) + EcDsbB (mutant) - NMR<BR />
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[[2k73]], [[2k74]] - EcDsbB (mutant) - NMR<BR />
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[[1fo5]] – PDOR – ''Methanocaldococcus jannaschii'' – NMR<BR />
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[[2ayt]] – PDOR – ''Aquifex aeolicus''<br />
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[[2hls]] – PDOR – ''Aeropyrus pernix''<br />
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[[2rem]] - DsbA + peptide – ''Xylella fastidiosa''<br />
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[[1st9]], [[1su9]], [[2f9s]], [[2h1d]] – BsResA soluble domain – ''Bacillus subtilis''<br />
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[[2h19]], [[2h1a]], [[2h1b]], [[2h1g]], [[3c71]], [[3c73]] - BsResA soluble domain (mutant) <br />
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[[3bci]] – SaDsbA – Staphylococcus aureus<br />
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[[3bck]], [[3bd2]] - SaDsbA (mutant) <br />
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[[3gh9]] - SaBdbB<br />
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[[3erw]] – SaPDOR sporulation<br />
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[[3fkf]] – PDOR – Bacterioides fragilis<br />
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[[2zuq]] - EcDsbB (mutant) + antibody
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For DsbB see [[Thiol:disulfide interchange protein]].
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== References ==
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<references/>
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</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

DsbA (PDB entry 3bci)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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