2v6g
From Proteopedia
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| - | [[Image:2v6g.jpg|left|200px]]<br /><applet load="2v6g" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2v6g, resolution 2.30Å" /> | ||
| - | '''STRUCTURE OF PROGESTERONE 5BETA-REDUCTASE FROM DIGITALIS LANATA IN COMPLEX WITH NADP'''<br /> | ||
| - | == | + | ==Structure of Progesterone 5beta-Reductase from Digitalis Lanata in complex with NADP== |
| - | + | <StructureSection load='2v6g' size='340' side='right'caption='[[2v6g]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2v6g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Digitalis_lanata Digitalis lanata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V6G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V6G FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v6g OCA], [https://pdbe.org/2v6g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v6g RCSB], [https://www.ebi.ac.uk/pdbsum/2v6g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v6g ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/5BPOR_DIGLA 5BPOR_DIGLA] Involved in cardenolide biosynthesis. Catalyzes the stereospecific conversion of progesterone to 5-beta-pregnane-3,20-dione. Can use progesterone, testosterone, 4-androstene-3,17-dione, cortisol and cortisone as substrates, but not pregnenolone, 21-OH-pregnenolone or isoprogesterone. NADPH could not be replaced by NADH.<ref>PMID:16386278</ref> <ref>PMID:18032383</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v6/2v6g_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v6g ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Digitalis lanata]] | [[Category: Digitalis lanata]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Egerer-Sieber | + | [[Category: Egerer-Sieber C]] |
| - | [[Category: Herl | + | [[Category: Herl V]] |
| - | [[Category: Jaeger | + | [[Category: Jaeger C]] |
| - | [[Category: Kreis | + | [[Category: Kreis W]] |
| - | [[Category: Mueller-Uri | + | [[Category: Mueller-Uri F]] |
| - | [[Category: Muller | + | [[Category: Muller YA]] |
| - | [[Category: Thorn | + | [[Category: Thorn A]] |
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Current revision
Structure of Progesterone 5beta-Reductase from Digitalis Lanata in complex with NADP
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