4hvy

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{{STRUCTURE_4hvy| PDB=4hvy | SCENE= }}
 
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===A thermostable variant of human NUDT18 NUDIX domain obtained by Hot Colony Filtration===
 
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{{ABSTRACT_PUBMED_24352381}}
 
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==Function==
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==A thermostable variant of human NUDT18 NUDIX domain obtained by Hot Colony Filtration==
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[[http://www.uniprot.org/uniprot/NUD18_HUMAN NUD18_HUMAN]] Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools.
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<StructureSection load='4hvy' size='340' side='right'caption='[[4hvy]], [[Resolution|resolution]] 1.46&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4hvy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HVY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HVY FirstGlance]. <br>
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[[4hvy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HVY OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.46&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hvy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hvy OCA], [https://pdbe.org/4hvy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hvy RCSB], [https://www.ebi.ac.uk/pdbsum/4hvy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hvy ProSAT]</span></td></tr>
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<ref group="xtra">PMID:024352381</ref><references group="xtra"/><references/>
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</table>
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[[Category: Asial, I.]]
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== Function ==
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[[Category: Cheng, Y X.]]
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[https://www.uniprot.org/uniprot/NUD18_HUMAN NUD18_HUMAN] Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools.
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[[Category: Cornvik, T.]]
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__TOC__
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[[Category: Dollhopf, M.]]
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</StructureSection>
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[[Category: Engman, H.]]
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[[Category: Homo sapiens]]
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[[Category: Nordlund, P.]]
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[[Category: Large Structures]]
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[[Category: Wu, B.]]
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[[Category: Asial I]]
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[[Category: Directed evolution]]
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[[Category: Cheng YX]]
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[[Category: Hot colony filtration]]
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[[Category: Cornvik T]]
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[[Category: Hot-cofi]]
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[[Category: Dollhopf M]]
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[[Category: Hydrolase]]
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[[Category: Engman H]]
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[[Category: Thermostability]]
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[[Category: Nordlund P]]
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[[Category: Wu B]]

Current revision

A thermostable variant of human NUDT18 NUDIX domain obtained by Hot Colony Filtration

PDB ID 4hvy

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