4i9z

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:13, 8 November 2023) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_4i9z| PDB=4i9z | SCENE= }}
 
-
===Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors===
 
-
{{ABSTRACT_PUBMED_23867165}}
 
-
==Function==
+
==Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors==
-
[[http://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
+
<StructureSection load='4i9z' size='340' side='right'caption='[[4i9z]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4i9z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I9Z FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5BA:5-BROMO-2-{5-[(4-METHYLPIPERAZIN-1-YL)ACETYL]-2-PROPOXYPHENYL}-6-(PROPAN-2-YL)PYRIMIDIN-4(3H)-ONE'>5BA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i9z OCA], [https://pdbe.org/4i9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i9z RCSB], [https://www.ebi.ac.uk/pdbsum/4i9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i9z ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The substituents both at the 6-position of the 5-bromopyrimidinone ring and at the 5'-position of the phenyl ring of 5-bromopyrimidin-4(3H)-ones were explored. 5-Bromo-6-isopropyl-2-(2-propoxy-phenyl)pyrimidin-4(3H)-one was identified as a new scaffold for potent PDE5 inhibitors. The crystal structures of PDE5/2e and PDE5/10a complexes provided a structural basis for the inhibition of 5-bromopyrimidinones to PDE5. In addition, it was also found that there is a great tolerance for the substitution at the 5'-position of the phenyl ring of 5-bormopyrimidinones and the resulted compound 13a has the highest inhibition activity to PDE5 (IC50, 1.7 nM).
-
==About this Structure==
+
Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5.,Gong X, Wang G, Ren J, Liu Z, Wang Z, Chen T, Yang X, Jiang X, Shen J, Jiang H, Aisa HA, Xu Y, Li J Bioorg Med Chem Lett. 2013 Sep 1;23(17):4944-7. doi: 10.1016/j.bmcl.2013.06.062. , Epub 2013 Jun 29. PMID:23867165<ref>PMID:23867165</ref>
-
[[4i9z]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I9Z OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<ref group="xtra">PMID:023867165</ref><references group="xtra"/><references/>
+
</div>
-
[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
+
<div class="pdbe-citations 4i9z" style="background-color:#fffaf0;"></div>
-
[[Category: Chen, T.]]
+
 
-
[[Category: Ren, J.]]
+
==See Also==
-
[[Category: Xu, Y.]]
+
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
-
[[Category: Hydrolase]]
+
== References ==
-
[[Category: Hydrolase-hydrolase inhibitor complex]]
+
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Chen T]]
 +
[[Category: Ren J]]
 +
[[Category: Xu Y]]

Current revision

Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors

PDB ID 4i9z

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4i9z"
Personal tools