4mya
From Proteopedia
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| - | {{STRUCTURE_4mya| PDB=4mya | SCENE= }} | ||
| - | ===Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase with an Internal Deletion of the CBS Domain from Bacillus anthracis str. Ames complexed with inhibitor A110=== | ||
| - | == | + | ==Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase with an Internal Deletion of the CBS Domain from Bacillus anthracis str. Ames complexed with inhibitor A110== |
| - | [[http://www.uniprot.org/uniprot/ | + | <StructureSection load='4mya' size='340' side='right'caption='[[4mya]], [[Resolution|resolution]] 1.90Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4mya]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis_str._Ames Bacillus anthracis str. Ames]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MYA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MYA FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8997Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2EY:4-{(1R)-1-[1-(4-CHLOROPHENYL)-1H-1,2,3-TRIAZOL-4-YL]ETHOXY}QUINOLIN-2(1H)-ONE'>2EY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mya OCA], [https://pdbe.org/4mya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mya RCSB], [https://www.ebi.ac.uk/pdbsum/4mya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mya ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A6L8P2U9_BACAN A0A6L8P2U9_BACAN] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964] | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | [[Category: | + | [[Category: Bacillus anthracis str. Ames]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Anderson WF]] |
| - | [[Category: | + | [[Category: CSGID]] |
| - | [[Category: | + | [[Category: Gorla SK]] |
| - | [[Category: | + | [[Category: Gu M]] |
| - | [[Category: | + | [[Category: Hedstrom L]] |
| - | [[Category: | + | [[Category: Joachimiak A]] |
| - | [[Category: | + | [[Category: Kim Y]] |
| - | [[Category: | + | [[Category: Makowska-Grzyska M]] |
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Current revision
Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase with an Internal Deletion of the CBS Domain from Bacillus anthracis str. Ames complexed with inhibitor A110
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