4mz1

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{{STRUCTURE_4mz1| PDB=4mz1 | SCENE= }}
 
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===Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase, with a Internal Deletion of CBS Domain from Campylobacter jejuni complexed with inhibitor compound P12===
 
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==Function==
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==Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase, with a Internal Deletion of CBS Domain from Campylobacter jejuni complexed with inhibitor compound P12==
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[[http://www.uniprot.org/uniprot/Q0P9J4_CAMJE Q0P9J4_CAMJE]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).[HAMAP-Rule:MF_01964]
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<StructureSection load='4mz1' size='340' side='right'caption='[[4mz1]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4mz1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_jejuni_subsp._jejuni_NCTC_11168_=_ATCC_700819 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MZ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MZ1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3991&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2F1:1-(4-BROMOPHENYL)-3-{2-[3-(PROP-1-EN-2-YL)PHENYL]PROPAN-2-YL}UREA'>2F1</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mz1 OCA], [https://pdbe.org/4mz1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mz1 RCSB], [https://www.ebi.ac.uk/pdbsum/4mz1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mz1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q0P9J4_CAMJE Q0P9J4_CAMJE] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).[HAMAP-Rule:MF_01964]
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==About this Structure==
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==See Also==
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[[4mz1]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MZ1 OCA].
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*[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]]
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[[Category: IMP dehydrogenase]]
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__TOC__
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[[Category: Anderson, W F.]]
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</StructureSection>
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[[Category: CSGID, Center for Structural Genomics of Infectious Diseases.]]
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[[Category: Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]]
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[[Category: Csgid]]
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[[Category: Large Structures]]
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[[Category: Gu, M.]]
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[[Category: Anderson WF]]
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[[Category: Joachimiak, A.]]
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[[Category: CSGID]]
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[[Category: Kim, Y.]]
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[[Category: Gu M]]
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[[Category: Makowska-Grzyska, M.]]
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[[Category: Joachimiak A]]
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[[Category: Alpha-beta structure]]
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[[Category: Kim Y]]
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[[Category: Center for structural genomics of infectious disease]]
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[[Category: Makowska-Grzyska M]]
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[[Category: Csgid]]
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[[Category: National institute of allergy and infectious disease]]
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[[Category: Niaid]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Structural genomic]]
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[[Category: Tim barrel]]
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Current revision

Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase, with a Internal Deletion of CBS Domain from Campylobacter jejuni complexed with inhibitor compound P12

PDB ID 4mz1

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