4ley

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:19, 1 March 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_4ley| PDB=4ley | SCENE= }}
 
-
===Structure of mouse cGAS bound to 18 bp DNA===
 
-
{{ABSTRACT_PUBMED_24332030}}
 
-
==Function==
+
==Structure of mouse cGAS bound to 18 bp DNA==
-
[[http://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
+
<StructureSection load='4ley' size='340' side='right'caption='[[4ley]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4ley]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LEY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LEY FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ley FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ley OCA], [https://pdbe.org/4ley PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ley RCSB], [https://www.ebi.ac.uk/pdbsum/4ley PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ley ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
-
==About this Structure==
+
==See Also==
-
[[4ley]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LEY OCA].
+
*[[Cyclic GMP-AMP synthase 3D synthase|Cyclic GMP-AMP synthase 3D synthase]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:024332030</ref><references group="xtra"/><references/>
+
[[Category: Large Structures]]
-
[[Category: Li, P.]]
+
[[Category: Mus musculus]]
-
[[Category: Dna sensor]]
+
[[Category: Li P]]
-
[[Category: Ntase]]
+
-
[[Category: Transferase-dna complex]]
+

Current revision

Structure of mouse cGAS bound to 18 bp DNA

PDB ID 4ley

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4ley"
Personal tools