4gwt

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{{STRUCTURE_4gwt| PDB=4gwt | SCENE= }}
 
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===Structure of racemic Pin1 WW domain cocrystallized with DL-malic acid===
 
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{{ABSTRACT_PUBMED_24311591}}
 
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==Function==
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==Structure of racemic Pin1 WW domain cocrystallized with DL-malic acid==
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[[http://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN]] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
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<StructureSection load='4gwt' size='340' side='right'caption='[[4gwt]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gwt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GWT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LMR:(2S)-2-HYDROXYBUTANEDIOIC+ACID'>LMR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gwt OCA], [https://pdbe.org/4gwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gwt RCSB], [https://www.ebi.ac.uk/pdbsum/4gwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gwt ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
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==About this Structure==
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==See Also==
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[[4gwt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GWT OCA].
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*[[Peptidyl-prolyl cis-trans isomerase 3D structures|Peptidyl-prolyl cis-trans isomerase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:024311591</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Peptidylprolyl isomerase]]
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</StructureSection>
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[[Category: Forest, K T.]]
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[[Category: Homo sapiens]]
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[[Category: Gellman, S H.]]
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[[Category: Large Structures]]
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[[Category: Mortenson, D E.]]
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[[Category: Forest KT]]
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[[Category: Yun, H G.]]
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[[Category: Gellman SH]]
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[[Category: Proline phosphoser/thr binding]]
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[[Category: Mortenson DE]]
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[[Category: Protein binding]]
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[[Category: Yun HG]]
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[[Category: Racemic crystallization]]
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[[Category: Ww domain]]
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Current revision

Structure of racemic Pin1 WW domain cocrystallized with DL-malic acid

PDB ID 4gwt

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