2vi9

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[[Image:2vi9.jpg|left|200px]]<br /><applet load="2vi9" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2vi9, resolution 2.00&Aring;" />
 
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'''CRYSTAL STRUCTURE OF S172ABSSHMT GLYCINE EXTERNAL ALDIMINE'''<br />
 
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==About this Structure==
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==Crystal structure of S172AbsSHMT Glycine external aldimine==
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2VI9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=GLY:'>GLY</scene> and <scene name='pdbligand=MPD:'>MPD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] Known structural/functional Sites: <scene name='pdbsite=AC1:Plp+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:GLY+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Mpd+Binding+Site+For+Chain+A'>AC3</scene> and <scene name='pdbsite=AC4:Mpd+Binding+Site+For+Chain+A'>AC4</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VI9 OCA].
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<StructureSection load='2vi9' size='340' side='right'caption='[[2vi9]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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[[Category: Geobacillus stearothermophilus]]
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== Structural highlights ==
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[[Category: Glycine hydroxymethyltransferase]]
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<table><tr><td colspan='2'>[[2vi9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VI9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VI9 FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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[[Category: Bhavani, B S.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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[[Category: Murthy, M R.N.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vi9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vi9 OCA], [https://pdbe.org/2vi9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vi9 RCSB], [https://www.ebi.ac.uk/pdbsum/2vi9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vi9 ProSAT]</span></td></tr>
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[[Category: Prakash, V.]]
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</table>
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[[Category: Rajaram, V.]]
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== Function ==
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[[Category: Rao, N Appaji.]]
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[https://www.uniprot.org/uniprot/Q7SIB6_GEOSE Q7SIB6_GEOSE] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.[HAMAP-Rule:MF_00051]
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[[Category: Savithri, H S.]]
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== Evolutionary Conservation ==
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[[Category: GLY]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: MPD]]
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Check<jmol>
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[[Category: PO4]]
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<jmolCheckbox>
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[[Category: e53q]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vi/2vi9_consurf.spt"</scriptWhenChecked>
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[[Category: enzyme memory]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: fthf]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: one-carbon metabolism]]
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</jmolCheckbox>
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[[Category: plp-dependent enzymes]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vi9 ConSurf].
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[[Category: pyridoxal phosphate]]
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<div style="clear:both"></div>
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[[Category: shmt]]
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[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:56:02 2008''
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==See Also==
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*[[Serine hydroxymethyltransferase 3D structures|Serine hydroxymethyltransferase 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Geobacillus stearothermophilus]]
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[[Category: Large Structures]]
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[[Category: Appaji Rao N]]
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[[Category: Bhavani BS]]
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[[Category: Murthy MRN]]
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[[Category: Prakash V]]
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[[Category: Rajaram V]]
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[[Category: Savithri HS]]

Current revision

Crystal structure of S172AbsSHMT Glycine external aldimine

PDB ID 2vi9

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