4ne1
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human MHF1 MHF2 DNA complexes== | |
| + | <StructureSection load='4ne1' size='340' side='right'caption='[[4ne1]], [[Resolution|resolution]] 6.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4ne1]] is a 48 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NE1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NE1 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 6.499Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ne1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ne1 OCA], [https://pdbe.org/4ne1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ne1 RCSB], [https://www.ebi.ac.uk/pdbsum/4ne1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ne1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CENPS_HUMAN CENPS_HUMAN] DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Required for optimal chromatin association of the FA core complex. Required for efficient damage-induced monoubiquitination and focus formation of FANCD2. Stabilizes FAAD24, FANCM and STRA13/CENPX in the FA core complex. Plays a role in DNA interstrand cross-linking (ICL) repair and in recovery of replication forks stalled by topoisomerase I-DNA cleavage intermediates induced by camptothecin. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation. Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.<ref>PMID:19620631</ref> <ref>PMID:22814378</ref> [REFERENCE:8] | ||
| - | + | ==See Also== | |
| - | + | *[[Centromere protein 3D structure|Centromere protein 3D structure]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Sachpatzidis A]] | ||
| + | [[Category: Saro D]] | ||
| + | [[Category: Sung P]] | ||
| + | [[Category: Xiong Y]] | ||
| + | [[Category: Zhao Q]] | ||
Current revision
Human MHF1 MHF2 DNA complexes
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