2yqr
From Proteopedia
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| - | [[Image:2yqr.gif|left|200px]]<br /><applet load="2yqr" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2yqr" /> | ||
| - | '''Solution structure of the KH domain in KIAA0907 protein'''<br /> | ||
| - | == | + | ==Solution structure of the KH domain in KIAA0907 protein== |
| - | + | <StructureSection load='2yqr' size='340' side='right'caption='[[2yqr]]' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2yqr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YQR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YQR FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yqr OCA], [https://pdbe.org/2yqr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yqr RCSB], [https://www.ebi.ac.uk/pdbsum/2yqr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yqr ProSAT], [https://www.topsan.org/Proteins/RSGI/2yqr TOPSAN]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KHDC4_HUMAN KHDC4_HUMAN] RNA-binding protein involved in pre-mRNA splicing (PubMed:19641227). Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome (PubMed:19641227). Involved in regulating splice site selection (PubMed:19641227). Binds preferentially RNA with A/C rich sequences and poly-C stretches (PubMed:23144703).<ref>PMID:19641227</ref> <ref>PMID:23144703</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yq/2yqr_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yqr ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: He | + | [[Category: He F]] |
| - | [[Category: Inoue | + | [[Category: Inoue M]] |
| - | [[Category: Kadirvel | + | [[Category: Kadirvel S]] |
| - | [[Category: Kigawa | + | [[Category: Kigawa T]] |
| - | [[Category: Muto | + | [[Category: Muto Y]] |
| - | + | [[Category: Shirouzu M]] | |
| - | [[Category: Shirouzu | + | [[Category: Tarada T]] |
| - | [[Category: Tarada | + | [[Category: Yokoyama S]] |
| - | [[Category: Yokoyama | + | |
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Current revision
Solution structure of the KH domain in KIAA0907 protein
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Categories: Homo sapiens | Large Structures | He F | Inoue M | Kadirvel S | Kigawa T | Muto Y | Shirouzu M | Tarada T | Yokoyama S
