4hs2

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{{STRUCTURE_4hs2| PDB=4hs2 | SCENE= }}
 
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===Crystal Structure of the Human SPOP C-terminal Domain===
 
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{{ABSTRACT_PUBMED_23999291}}
 
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==Function==
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==Crystal Structure of the Human SPOP C-terminal Domain==
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[[http://www.uniprot.org/uniprot/SPOP_HUMAN SPOP_HUMAN]] Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex (By similarity). In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3.<ref>PMID:14528312</ref> <ref>PMID:15897469</ref> <ref>PMID:16524876</ref>
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<StructureSection load='4hs2' size='340' side='right'caption='[[4hs2]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4hs2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HS2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hs2 OCA], [https://pdbe.org/4hs2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hs2 RCSB], [https://www.ebi.ac.uk/pdbsum/4hs2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hs2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPOP_HUMAN SPOP_HUMAN] Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex (By similarity). In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3.<ref>PMID:14528312</ref> <ref>PMID:15897469</ref> <ref>PMID:16524876</ref>
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==About this Structure==
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==See Also==
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[[4hs2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HS2 OCA].
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*[[Speckle-type POZ protein 3D structures|Speckle-type POZ protein 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:023999291</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Human]]
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</StructureSection>
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[[Category: Carr, S B.]]
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[[Category: Homo sapiens]]
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[[Category: Geersdaele, L K.Van.]]
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[[Category: Large Structures]]
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[[Category: Stead, M A.]]
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[[Category: Carr SB]]
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[[Category: Wright, S C.]]
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[[Category: Stead MA]]
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[[Category: Oligomerisation]]
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[[Category: Van Geersdaele LK]]
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[[Category: Protein binding]]
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[[Category: Wright SC]]
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[[Category: Protein interaction domain]]
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Current revision

Crystal Structure of the Human SPOP C-terminal Domain

PDB ID 4hs2

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