4ly9

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{{STRUCTURE_4ly9| PDB=4ly9 | SCENE= }}
 
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===Human GKRP complexed to AMG-1694 [(2R)-1,1,1-trifluoro-2-{4-[(2S)-2-{[(3S)-3-methylmorpholin-4-yl]methyl}-4-(thiophen-2-ylsulfonyl)piperazin-1-yl]phenyl}propan-2-ol] and sorbitol-6-phosphate===
 
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{{ABSTRACT_PUBMED_24226772}}
 
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==Function==
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==Human GKRP complexed to AMG-1694 [(2R)-1,1,1-trifluoro-2-{4-[(2S)-2-{[(3S)-3-methylmorpholin-4-yl]methyl}-4-(thiophen-2-ylsulfonyl)piperazin-1-yl]phenyl}propan-2-ol] and sorbitol-6-phosphate==
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[[http://www.uniprot.org/uniprot/GCKR_HUMAN GCKR_HUMAN]] Inhibits glucokinase by forming an inactive complex with this enzyme.
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<StructureSection load='4ly9' size='340' side='right'caption='[[4ly9]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ly9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LY9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1YY:(2R)-1,1,1-TRIFLUORO-2-{4-[(2S)-2-{[(3S)-3-METHYLMORPHOLIN-4-YL]METHYL}-4-(THIOPHEN-2-YLSULFONYL)PIPERAZIN-1-YL]PHENYL}PROPAN-2-OL'>1YY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=S6P:D-SORBITOL-6-PHOSPHATE'>S6P</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ly9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ly9 OCA], [https://pdbe.org/4ly9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ly9 RCSB], [https://www.ebi.ac.uk/pdbsum/4ly9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ly9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GCKR_HUMAN GCKR_HUMAN] Inhibits glucokinase by forming an inactive complex with this enzyme.
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==About this Structure==
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==See Also==
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[[4ly9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LY9 OCA].
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*[[Glucokinase Regulatory Protein|Glucokinase Regulatory Protein]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:024226772</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Jordan, S R.]]
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[[Category: Jordan SR]]
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[[Category: Carbohydrate binding protein]]
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[[Category: Disruptor ligand complex]]
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[[Category: Gkrp binds to gk]]
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[[Category: Liver]]
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[[Category: Regulatory protein]]
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[[Category: Sis domain]]
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Current revision

Human GKRP complexed to AMG-1694 [(2R)-1,1,1-trifluoro-2-{4-[(2S)-2-{[(3S)-3-methylmorpholin-4-yl]methyl}-4-(thiophen-2-ylsulfonyl)piperazin-1-yl]phenyl}propan-2-ol] and sorbitol-6-phosphate

PDB ID 4ly9

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