3pz4

{{STRUCTURE_3pz4| PDB=3pz4 | SCENE= }}

===Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BMS3 and lipid substrate FPP===

==Function==

[[http://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT]] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity). [[http://www.uniprot.org/uniprot/FNTB_RAT FNTB_RAT]] Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.

 

[[3pz4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ4 OCA].

*[[Farnesyltransferase|Farnesyltransferase]]

 

<ref group="xtra">PMID:021520375</ref><references group="xtra"/><references/>

[[Category: Lk3 transgenic mice]]

[[Category: Protein farnesyltransferase]]

[[Category: Alexandrov, K.]]

[[Category: Blankenfeldt, W.]]

[[Category: Bon, R S.]]

[[Category: Goody, R S.]]

[[Category: Guo, Z.]]

[[Category: Stigter, E A.]]

[[Category: Waldmann, H.]]

[[Category: Transferase-transferase inhibitor complex]]