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4kjj

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{{STRUCTURE_4kjj| PDB=4kjj | SCENE= }}
 
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===Cryogenic WT DHFR===
 
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{{ABSTRACT_PUBMED_23913260}}
 
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==Function==
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==Cryogenic WT DHFR==
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[[http://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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<StructureSection load='4kjj' size='340' side='right'caption='[[4kjj]], [[Resolution|resolution]] 1.15&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4kjj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KJJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KJJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kjj OCA], [https://pdbe.org/4kjj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kjj RCSB], [https://www.ebi.ac.uk/pdbsum/4kjj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kjj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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==About this Structure==
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==See Also==
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[[4kjj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KJJ OCA].
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:023913260</ref><references group="xtra"/><references/>
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[[Category: Escherichia coli K-12]]
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[[Category: Dihydrofolate reductase]]
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[[Category: Large Structures]]
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[[Category: Ecoli]]
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[[Category: Bhabha G]]
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[[Category: Bedem, H van den.]]
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[[Category: Fraser JS]]
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[[Category: Bhabha, G.]]
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[[Category: Wright PE]]
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[[Category: Fraser, J S.]]
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[[Category: Yang K]]
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[[Category: Wright, P E.]]
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[[Category: Van den Bedem H]]
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[[Category: Yang, K.]]
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[[Category: Oxidoreductase]]
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[[Category: Rossman fold]]
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Current revision

Cryogenic WT DHFR

PDB ID 4kjj

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