2ywr

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{{STRUCTURE_2ywr| PDB=2ywr | SCENE= }}
 
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===Crystal structure of GAR transformylase from Aquifex aeolicus===
 
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{{ABSTRACT_PUBMED_24108189}}
 
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==About this Structure==
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==Crystal structure of GAR transformylase from Aquifex aeolicus==
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[[2ywr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YWR OCA].
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<StructureSection load='2ywr' size='340' side='right'caption='[[2ywr]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ywr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YWR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YWR FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ywr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ywr OCA], [https://pdbe.org/2ywr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ywr RCSB], [https://www.ebi.ac.uk/pdbsum/2ywr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ywr ProSAT], [https://www.topsan.org/Proteins/RSGI/2ywr TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O67023_AQUAE O67023_AQUAE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yw/2ywr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ywr ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structures of glycinamide ribonucleotide transformylases (PurNs) from Aquifex aeolicus (Aa), Geobacillus kaustophilus (Gk) and Symbiobacterium toebii (St), and of formyltetrahydrofolate hydrolase (PurU) from Thermus thermophilus (Tt) were determined. The monomer structures of the determined PurN and PurU were very similar to the known structure of PurN, but oligomeric states were different; AaPurN and StPurN formed dimers, GkPurN formed monomer and PurU formed tetramer in the crystals. PurU had a regulatory ACT domain in its N-terminal side. So far several structures of PurUs have been determined, yet, the mechanisms of the catalysis and the regulation of PurU have not been elucidated. We, therefore, modelled ligand-bound structures of PurN and PurU, and performed molecular dynamics simulations to elucidate the reaction mechanisms. The evolutionary relationship of the two enzymes is discussed based on the comparisons of the structures and the catalytic mechanisms.
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==Reference==
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Structures and reaction mechanisms of the two related enzymes, PurN and PurU.,Sampei G, Kanagawa M, Baba S, Shimasaki T, Taka H, Mitsui S, Fujiwara S, Yanagida Y, Kusano M, Suzuki S, Terao K, Kawai H, Fukai Y, Nakagawa N, Ebihara A, Kuramitsu S, Yokoyama S, Kawai G J Biochem. 2013 Dec;154(6):569-79. doi: 10.1093/jb/mvt090. Epub 2013 Oct 9. PMID:24108189<ref>PMID:24108189</ref>
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<ref group="xtra">PMID:024108189</ref><references group="xtra"/><references/>
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[[Category: Aquifex aeolicus huber and stetter 2001]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Phosphoribosylglycinamide formyltransferase]]
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</div>
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[[Category: Baba, S.]]
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<div class="pdbe-citations 2ywr" style="background-color:#fffaf0;"></div>
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[[Category: Kanagawa, M.]]
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== References ==
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[[Category: Kawai, G.]]
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<references/>
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[[Category: Kuramitsu, S.]]
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__TOC__
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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</StructureSection>
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[[Category: Sampei, G.]]
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[[Category: Aquifex aeolicus]]
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[[Category: Yokoyama, S.]]
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[[Category: Large Structures]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Baba S]]
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[[Category: Nppsfa]]
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[[Category: Kanagawa M]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Kawai G]]
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[[Category: Rossmann fold]]
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[[Category: Kuramitsu S]]
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[[Category: Rsgi]]
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[[Category: Sampei G]]
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[[Category: Structural genomic]]
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[[Category: Yokoyama S]]
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[[Category: Transferase]]
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Current revision

Crystal structure of GAR transformylase from Aquifex aeolicus

PDB ID 2ywr

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