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2yxm

From Proteopedia

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[[Image:2yxm.gif|left|200px]]<br /><applet load="2yxm" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2yxm, resolution 1.51&Aring;" />
 
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'''Crystal structure of I-set domain of human Myosin Binding ProteinC'''<br />
 
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==About this Structure==
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==Crystal structure of I-set domain of human Myosin Binding ProteinC==
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2YXM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXM OCA].
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<StructureSection load='2yxm' size='340' side='right'caption='[[2yxm]], [[Resolution|resolution]] 1.51&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2yxm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YXM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.51&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yxm OCA], [https://pdbe.org/2yxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yxm RCSB], [https://www.ebi.ac.uk/pdbsum/2yxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yxm ProSAT], [https://www.topsan.org/Proteins/RSGI/2yxm TOPSAN]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MYPC1_HUMAN MYPC1_HUMAN] Defects in MYBPC1 are the cause of arthrogryposis, distal, type 1B (DA1B) [MIM:[https://omim.org/entry/614335 614335]. A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 1 is characterized largely by camptodactyly and clubfoot. Hypoplasia and/or absence of some interphalangeal creases is common. The shoulders and hips are less frequently affected.<ref>PMID:20045868</ref> Note=Defects in MYBPC1 may be a cause of autosomal recessive lethal congenital contractural syndrome (LCCS), a severe, neonatally lethal form of arthrogryposis.<ref>PMID:22610851</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/MYPC1_HUMAN MYPC1_HUMAN] Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yx/2yxm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yxm ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Chen, L.]]
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[[Category: Chen L]]
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[[Category: Kishishita, S.]]
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[[Category: Kishishita S]]
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[[Category: Liu, Z.]]
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[[Category: Liu Z]]
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[[Category: Murayama, K.]]
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[[Category: Murayama K]]
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[[Category: Ohsawa, N.]]
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[[Category: Ohsawa N]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Shirouzu M]]
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[[Category: Shirouzu, M.]]
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[[Category: Terada T]]
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[[Category: Terada, T.]]
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[[Category: Wang B]]
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[[Category: Wang, B.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: cell adhesionn]]
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[[Category: cytoskeleton]]
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[[Category: i-set domain]]
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[[Category: myosin binding protein c]]
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[[Category: national project on protein structural and functional analyses]]
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[[Category: nppsfa]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomics]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:58:36 2008''
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Current revision

Crystal structure of I-set domain of human Myosin Binding ProteinC

PDB ID 2yxm

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