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4o9h

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'''Unreleased structure'''
 
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The entry 4o9h is ON HOLD
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==Structure of Interleukin-6 in complex with a Camelid Fab fragment==
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<StructureSection load='4o9h' size='340' side='right'caption='[[4o9h]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4o9h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O9H FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o9h OCA], [https://pdbe.org/4o9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o9h RCSB], [https://www.ebi.ac.uk/pdbsum/4o9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o9h ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN] Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[https://omim.org/entry/604302 604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.
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== Function ==
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[https://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.
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Authors: Klarenbeek, A., Blanchetot, C., Schragel, G., Sadi, A.S., Ongenae, N., Hemrika, W., Wijdenes, J., Spinelli, S., Desmyter, A., Cambillau, C., Hultberg, A., Kretz-rommel, A., Dreier, T., De_haard, H.J.W., Roovers, R.C.
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==See Also==
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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Description: Structure of Interleukin-6 in complex with a Camelid Fab fragment
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Lama glama]]
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[[Category: Large Structures]]
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[[Category: Blanchetot C]]
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[[Category: Cambillau C]]
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[[Category: De haard HJW]]
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[[Category: Desmyter A]]
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[[Category: Dreier T]]
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[[Category: Hemrika W]]
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[[Category: Hultberg A]]
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[[Category: Klarenbeek A]]
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[[Category: Kretz-rommel A]]
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[[Category: Ongenae N]]
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[[Category: Roovers RC]]
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[[Category: Sadi AS]]
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[[Category: Schragel G]]
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[[Category: Spinelli S]]
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[[Category: Wijdenes J]]

Current revision

Structure of Interleukin-6 in complex with a Camelid Fab fragment

PDB ID 4o9h

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