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2yzk
From Proteopedia
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| - | [[Image:2yzk.jpg|left|200px]]<br /><applet load="2yzk" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2yzk, resolution 1.80Å" /> | ||
| - | '''Crystal structure of orotate phosphoribosyltransferase from Aeropyrum pernix'''<br /> | ||
| - | == | + | ==Crystal structure of orotate phosphoribosyltransferase from Aeropyrum pernix== |
| - | + | <StructureSection load='2yzk' size='340' side='right'caption='[[2yzk]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | + | <table><tr><td colspan='2'>[[2yzk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Aerpx Aerpx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YZK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2YZK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotate_phosphoribosyltransferase Orotate phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.10 2.4.2.10] </span></td></tr> | |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2yzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yzk OCA], [http://pdbe.org/2yzk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yzk RCSB], [http://www.ebi.ac.uk/pdbsum/2yzk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yzk ProSAT], [http://www.topsan.org/Proteins/RSGI/2yzk TOPSAN]</span></td></tr> |
| - | [ | + | </table> |
| - | + | == Function == | |
| - | [[ | + | [[http://www.uniprot.org/uniprot/PYRE_AERPE PYRE_AERPE]] Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity). |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | [[ | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yz/2yzk_consurf.spt"</scriptWhenChecked> | |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | + | </jmolCheckbox> | |
| - | [ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yzk ConSurf]. |
| - | [[ | + | <div style="clear:both"></div> |
| - | + | ||
| - | + | ||
| - | + | ==See Also== | |
| + | *[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Aerpx]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Orotate phosphoribosyltransferase]] | ||
| + | [[Category: Baba, S]] | ||
| + | [[Category: Kanagawa, M]] | ||
| + | [[Category: Kawai, G]] | ||
| + | [[Category: Kuramitsu, S]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Sampei, G]] | ||
| + | [[Category: Yokoyama, S]] | ||
| + | [[Category: Glycosyltransferase]] | ||
| + | [[Category: Magnesium]] | ||
| + | [[Category: National project on protein structural and functional analyse]] | ||
| + | [[Category: Nppsfa]] | ||
| + | [[Category: Pyrimidine biosynthesis]] | ||
| + | [[Category: Rossmann fold]] | ||
| + | [[Category: Rsgi]] | ||
| + | [[Category: Transferase]] | ||
Current revision
Crystal structure of orotate phosphoribosyltransferase from Aeropyrum pernix
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Categories: Aerpx | Large Structures | Orotate phosphoribosyltransferase | Baba, S | Kanagawa, M | Kawai, G | Kuramitsu, S | Structural genomic | Sampei, G | Yokoyama, S | Glycosyltransferase | Magnesium | National project on protein structural and functional analyse | Nppsfa | Pyrimidine biosynthesis | Rossmann fold | Rsgi | Transferase
