4n6x

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{{STRUCTURE_4n6x| PDB=4n6x | SCENE= }}
 
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===Crystal Structure of the Chemokine Receptor CXCR2 in Complex with the First PDZ Domain of NHERF1===
 
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{{ABSTRACT_PUBMED_24339979}}
 
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==Disease==
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==Crystal Structure of the Chemokine Receptor CXCR2 in Complex with the First PDZ Domain of NHERF1==
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[[http://www.uniprot.org/uniprot/NHRF1_HUMAN NHRF1_HUMAN]] Defects in SLC9A3R1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 2 (NPHLOP2) [MIM:[http://omim.org/entry/612287 612287]]. Hypophosphatemia results from idiopathic renal phosphate loss. It contributes to the pathogenesis of hypophosphatemic urolithiasis (formation of urinary calculi) as well to that of hypophosphatemic osteoporosis (bone demineralization).<ref>PMID:18784102</ref> <ref>PMID:22506049</ref>
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<StructureSection load='4n6x' size='340' side='right'caption='[[4n6x]], [[Resolution|resolution]] 1.05&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4n6x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N6X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N6X FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.051&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n6x OCA], [https://pdbe.org/4n6x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n6x RCSB], [https://www.ebi.ac.uk/pdbsum/4n6x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n6x ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/NHRF1_HUMAN NHRF1_HUMAN] Defects in SLC9A3R1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 2 (NPHLOP2) [MIM:[https://omim.org/entry/612287 612287]. Hypophosphatemia results from idiopathic renal phosphate loss. It contributes to the pathogenesis of hypophosphatemic urolithiasis (formation of urinary calculi) as well to that of hypophosphatemic osteoporosis (bone demineralization).<ref>PMID:18784102</ref> <ref>PMID:22506049</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/NHRF1_HUMAN NHRF1_HUMAN] Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules.<ref>PMID:9430655</ref> <ref>PMID:9096337</ref> <ref>PMID:10499588</ref> <ref>PMID:18784102</ref>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/NHRF1_HUMAN NHRF1_HUMAN]] Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules.<ref>PMID:9430655</ref> <ref>PMID:9096337</ref> <ref>PMID:10499588</ref> <ref>PMID:18784102</ref>
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*[[Sodium-hydrogen exchange regulatory factor 3D structures|Sodium-hydrogen exchange regulatory factor 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[4n6x]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N6X OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Homo sapiens]]
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<ref group="xtra">PMID:024339979</ref><references group="xtra"/><references/>
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[[Category: Large Structures]]
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[[Category: Brunzelle, J.]]
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[[Category: Brunzelle J]]
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[[Category: Jiang, Y.]]
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[[Category: Jiang Y]]
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[[Category: Li, C.]]
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[[Category: Li C]]
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[[Category: Lu, G.]]
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[[Category: Lu G]]
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[[Category: Sirinupong, N.]]
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[[Category: Sirinupong N]]
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[[Category: Wu, Y.]]
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[[Category: Wu Y]]
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[[Category: Yang, Z.]]
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[[Category: Yang Z]]
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[[Category: Cxcr2]]
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[[Category: Inflammatory disease]]
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[[Category: Neutrophil]]
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[[Category: Nherf1]]
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[[Category: Signaling protein]]
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Current revision

Crystal Structure of the Chemokine Receptor CXCR2 in Complex with the First PDZ Domain of NHERF1

PDB ID 4n6x

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