4lyw

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{{STRUCTURE_4lyw| PDB=4lyw | SCENE= }}
 
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===Crystal Structure of BRD4(1) bound to inhibitor XD14===
 
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{{ABSTRACT_PUBMED_24272870}}
 
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==Disease==
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==Crystal Structure of BRD4(1) bound to inhibitor XD14==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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<StructureSection load='4lyw' size='340' side='right'caption='[[4lyw]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4lyw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LYW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LYW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=21Q:4-ACETYL-N-[5-(DIETHYLSULFAMOYL)-2-HYDROXYPHENYL]-3-ETHYL-5-METHYL-1H-PYRROLE-2-CARBOXAMIDE'>21Q</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lyw OCA], [https://pdbe.org/4lyw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lyw RCSB], [https://www.ebi.ac.uk/pdbsum/4lyw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lyw ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[4lyw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LYW OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Homo sapiens]]
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<ref group="xtra">PMID:024272870</ref><references group="xtra"/><references/>
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[[Category: Large Structures]]
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[[Category: Einsle, O.]]
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[[Category: Einsle O]]
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[[Category: Gerhardt, S.]]
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[[Category: Gerhardt S]]
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[[Category: Wohlwend, D.]]
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[[Category: Wohlwend D]]
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[[Category: Acetylated lysine]]
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[[Category: Brd4 inhibitor]]
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[[Category: Bromodomain]]
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[[Category: Epigenetic reader protein]]
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[[Category: Histone tail]]
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[[Category: Protein binding-inhibitor complex]]
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Current revision

Crystal Structure of BRD4(1) bound to inhibitor XD14

PDB ID 4lyw

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