4k8u
From Proteopedia
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- | {{STRUCTURE_4k8u| PDB=4k8u | SCENE= }} | ||
- | ===Crystal structure of TRAF4 TRAF domain=== | ||
- | == | + | ==Crystal structure of TRAF4 TRAF domain== |
- | [[http://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN | + | <StructureSection load='4k8u' size='340' side='right'caption='[[4k8u]], [[Resolution|resolution]] 2.30Å' scene=''> |
+ | == Structural highlights == | ||
+ | <table><tr><td colspan='2'>[[4k8u]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K8U FirstGlance]. <br> | ||
+ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.302Å</td></tr> | ||
+ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k8u OCA], [https://pdbe.org/4k8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k8u RCSB], [https://www.ebi.ac.uk/pdbsum/4k8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k8u ProSAT]</span></td></tr> | ||
+ | </table> | ||
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN] Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.<ref>PMID:12023963</ref> <ref>PMID:12801526</ref> <ref>PMID:16052631</ref> <ref>PMID:16157600</ref> <ref>PMID:18953416</ref> <ref>PMID:19937093</ref> | ||
- | == | + | ==See Also== |
- | [[ | + | *[[TNF receptor-associated factor 3D structures|TNF receptor-associated factor 3D structures]] |
- | + | == References == | |
- | == | + | <references/> |
- | <references | + | __TOC__ |
- | [[Category: | + | </StructureSection> |
- | [[Category: | + | [[Category: Homo sapiens]] |
- | [[Category: | + | [[Category: Large Structures]] |
- | [[Category: | + | [[Category: Park HH]] |
- | + | [[Category: Yoon JH]] | |
- | + | ||
- | + |
Current revision
Crystal structure of TRAF4 TRAF domain
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