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4kqv

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{{STRUCTURE_4kqv| PDB=4kqv | SCENE= }}
 
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===Topoisomerase iv atp binding domain of francisella tularensis in complex with a small molecule inhibitor===
 
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==About this Structure==
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==Topoisomerase iv atp binding domain of francisella tularensis in complex with a small molecule inhibitor==
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[[4kqv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQV OCA].
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<StructureSection load='4kqv' size='340' side='right'caption='[[4kqv]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
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[[Category: Akers-Rodriguez, S.]]
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== Structural highlights ==
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[[Category: Bensen, D C]]
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<table><tr><td colspan='2'>[[4kqv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Francisella_tularensis_subsp._holarctica_LVS Francisella tularensis subsp. holarctica LVS]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KQV FirstGlance]. <br>
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[[Category: Lam, T.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.38&#8491;</td></tr>
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[[Category: Tari, L W.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DOO:6-FLUORO-4-[(3AR,6AR)-HEXAHYDROPYRROLO[3,4-B]PYRROL-5(1H)-YL]-N-METHYL-2-[(2-METHYLPYRIMIDIN-5-YL)OXY]-9H-PYRIMIDO[4,5-B]INDOL-8-AMINE'>DOO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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[[Category: Atp-binding]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kqv OCA], [https://pdbe.org/4kqv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kqv RCSB], [https://www.ebi.ac.uk/pdbsum/4kqv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kqv ProSAT]</span></td></tr>
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[[Category: Atp-binding domain]]
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</table>
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[[Category: Dna gyrase negatively supercoils closed circular double-stranded dna]]
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== Function ==
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[[Category: Isomerase]]
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[https://www.uniprot.org/uniprot/PARE_FRATH PARE_FRATH] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA (PubMed:23352267, PubMed:23294697, PubMed:24386374). Performs the decatenation events required during the replication of a circular DNA molecule.[HAMAP-Rule:MF_00938]<ref>PMID:23352267</ref> <ref>PMID:24386374</ref> <ref>PMID:23294697</ref>
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[[Category: Nucleotide-binding]]
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[[Category: Topoisomerase]]
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==See Also==
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*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Francisella tularensis subsp. holarctica LVS]]
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[[Category: Large Structures]]
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[[Category: Akers-Rodriguez S]]
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[[Category: Bensen DC]]
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[[Category: Lam T]]
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[[Category: Tari LW]]

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Topoisomerase iv atp binding domain of francisella tularensis in complex with a small molecule inhibitor

PDB ID 4kqv

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