This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4nvq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:35, 1 March 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_4nvq| PDB=4nvq | SCENE= }}
 
-
===Human G9a in Complex with Inhibitor A-366===
 
-
==Function==
+
==Human G9a in Complex with Inhibitor A-366==
-
[[http://www.uniprot.org/uniprot/EHMT2_HUMAN EHMT2_HUMAN]] Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.<ref>PMID:8457211</ref> <ref>PMID:11316813</ref> <ref>PMID:18438403</ref> <ref>PMID:20118233</ref> <ref>PMID:22387026</ref>
+
<StructureSection load='4nvq' size='340' side='right'caption='[[4nvq]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4nvq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NVQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NVQ FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2OD:5-METHOXY-6-[3-(PYRROLIDIN-1-YL)PROPOXY]SPIRO[CYCLOBUTANE-1,3-INDOL]-2-AMINE'>2OD</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nvq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nvq OCA], [https://pdbe.org/4nvq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nvq RCSB], [https://www.ebi.ac.uk/pdbsum/4nvq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nvq ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/EHMT2_HUMAN EHMT2_HUMAN] Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.<ref>PMID:8457211</ref> <ref>PMID:11316813</ref> <ref>PMID:18438403</ref> <ref>PMID:20118233</ref> <ref>PMID:22387026</ref>
-
==About this Structure==
+
==See Also==
-
[[4nvq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NVQ OCA].
+
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<references group="xtra"/><references/>
+
__TOC__
-
[[Category: Brown, P J.]]
+
</StructureSection>
-
[[Category: Chiang, G G.]]
+
[[Category: Homo sapiens]]
-
[[Category: Guo, J.]]
+
[[Category: Large Structures]]
-
[[Category: Li, F.]]
+
[[Category: Brown PJ]]
-
[[Category: Maag, D.]]
+
[[Category: Chiang GG]]
-
[[Category: Michaelides, M R.]]
+
[[Category: Guo J]]
-
[[Category: Pappano, W N.]]
+
[[Category: Li F]]
-
[[Category: Petros, A M.]]
+
[[Category: Maag D]]
-
[[Category: Pliushchev, M.]]
+
[[Category: Michaelides MR]]
-
[[Category: Soni, N B.]]
+
[[Category: Pappano WN]]
-
[[Category: Sweis, R F.]]
+
[[Category: Petros AM]]
-
[[Category: Tse, C.]]
+
[[Category: Pliushchev M]]
-
[[Category: Vedadi, M.]]
+
[[Category: Soni NB]]
-
[[Category: Lysine methyl transferase]]
+
[[Category: Sweis RF]]
-
[[Category: Transferase-transferase inhibitor complex]]
+
[[Category: Tse C]]
 +
[[Category: Vedadi M]]

Current revision

Human G9a in Complex with Inhibitor A-366

PDB ID 4nvq

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4nvq"
Personal tools