4jc7

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{{STRUCTURE_4jc7| PDB=4jc7 | SCENE= }}
 
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===Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis===
 
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{{ABSTRACT_PUBMED_24366866}}
 
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==Disease==
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==Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis==
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[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[http://omim.org/entry/246530 246530]]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
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<StructureSection load='4jc7' size='340' side='right'caption='[[4jc7]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4jc7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JC7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTX:S-HEXYLGLUTATHIONE'>GTX</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jc7 OCA], [https://pdbe.org/4jc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jc7 RCSB], [https://www.ebi.ac.uk/pdbsum/4jc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jc7 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[https://omim.org/entry/246530 246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
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== Function ==
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[https://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
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*[[Leukotriene C4 synthase|Leukotriene C4 synthase]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4jc7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JC7 OCA].
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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==Reference==
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[[Category: Haeggstrom JZ]]
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<ref group="xtra">PMID:024366866</ref><references group="xtra"/><references/>
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[[Category: Niegowski D]]
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[[Category: Haeggstrom, J Z.]]
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[[Category: Rinaldo-Matthis A]]
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[[Category: Niegowski, D.]]
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[[Category: Rinaldo-Matthis, A.]]
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[[Category: Leukotriene c4 synthase]]
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[[Category: Lipid biosynthesis]]
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[[Category: Lyase]]
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[[Category: Product analog]]
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Current revision

Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis

PDB ID 4jc7

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