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4n6q
From Proteopedia
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| - | {{STRUCTURE_4n6q| PDB=4n6q | SCENE= }} | ||
| - | ===Crystal structure of VosA velvet domain=== | ||
| - | {{ABSTRACT_PUBMED_24391470}} | ||
| - | == | + | ==Crystal structure of VosA velvet domain== |
| - | [[4n6q]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N6Q OCA]. | + | <StructureSection load='4n6q' size='340' side='right'caption='[[4n6q]], [[Resolution|resolution]] 1.79Å' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[4n6q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_nidulans Aspergillus nidulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N6Q FirstGlance]. <br> |
| - | < | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79Å</td></tr> |
| - | [ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n6q OCA], [https://pdbe.org/4n6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n6q RCSB], [https://www.ebi.ac.uk/pdbsum/4n6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n6q ProSAT]</span></td></tr> |
| - | [ | + | </table> |
| - | [ | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/VOSA_EMENI VOSA_EMENI] Component of the velB-VosA heterodimeric complex that plays a dual role in activating genes associated with spore maturation and repressing certain development-associated genes (PubMed:17912349, PubMed:21152013, PubMed:23049895, PubMed:24391470). Controls primarily the late process of sporulation including trehalose biogenesis (PubMed:17912349). The complex binds DNA through the DNA-binding domain of vosA that recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3' consisting of two motifs in the promoters of key developmental regulatory genes (PubMed:24391470). The vosA-velB complex binds to the beta-glucan synthase fksA gene promoter in asexual spores for repression (PubMed:25960370).[UniProtKB:A0SP16]<ref>PMID:17912349</ref> <ref>PMID:21152013</ref> <ref>PMID:23049895</ref> <ref>PMID:25960370</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Aspergillus nidulans]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ahmed YL]] | ||
| + | [[Category: Dickmanns A]] | ||
| + | [[Category: Ficner R]] | ||
| + | [[Category: Neumann P]] | ||
Current revision
Crystal structure of VosA velvet domain
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