4nh9

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{{STRUCTURE_4nh9| PDB=4nh9 | SCENE= }}
 
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===Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity===
 
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{{ABSTRACT_PUBMED_24332488}}
 
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==Function==
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==Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity==
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[[http://www.uniprot.org/uniprot/ENPL_HUMAN ENPL_HUMAN]] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.<ref>PMID:18264092</ref>
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<StructureSection load='4nh9' size='340' side='right'caption='[[4nh9]], [[Resolution|resolution]] 2.77&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4nh9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NH9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NH9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.77&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2LC:2-FLUORO-6-[(3S)-TETRAHYDROFURAN-3-YLAMINO]-4-(3,6,6-TRIMETHYL-4-OXO-4,5,6,7-TETRAHYDRO-1H-INDOL-1-YL)BENZAMIDE'>2LC</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nh9 OCA], [https://pdbe.org/4nh9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nh9 RCSB], [https://www.ebi.ac.uk/pdbsum/4nh9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nh9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ENPL_HUMAN ENPL_HUMAN] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.<ref>PMID:18264092</ref>
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==About this Structure==
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==See Also==
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[[4nh9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NH9 OCA].
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:024332488</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Ernst, J T.]]
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</StructureSection>
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[[Category: Zuccola, H J.]]
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[[Category: Homo sapiens]]
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[[Category: A/b structure]]
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[[Category: Large Structures]]
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[[Category: Chaperone]]
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[[Category: Ernst JT]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Zuccola HJ]]

Current revision

Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity

PDB ID 4nh9

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